Lerivon pills 30mg №20

Indications and usage

Depressive syndrome of various genesis requiring pharmacotherapy.

Contraindications

- Manic syndrome.
- Severe abnormal liver function.

Pregnancy and Breastfeeding

The use of Lerivon during pregnancy is possible only if absolutely necessary.

Dosage and administration

The dosage regimen is set individually and adjusted in the course of treatment, depending on the response of the patient. Adults are prescribed in an initial daily dose of 30-45 mg.Effective therapeutic dose ranges from 30-90 mg / day. The daily dose can be divided into several doses, or, preferably, administered once a night (given the positive effect on sleep). It is advisable to continue antidepressant therapy for a few more months after reaching the clinical effect. For elderly patients, doses are adjusted individually, starting at 30 mg / day. Then the daily dose may be gradually increased. The maintenance effective dose may be slightly lower than for middle-aged patients. For use in children there are no recommendations because of the limited experience of the clinical use of the drug in this category of patients.

Special notes

It is necessary to observe the usual caution when prescribing Lerivon to patients with diabetes mellitus (some patients may require correction of hypoglycemic therapy), patients with diseases of the cardiovascular system, renal and hepatic insufficiency. In the process of treatment with Lerivon, one should refrain from drinking alcohol due to the potentiation of the latter’s action on the CNS. A study of the pattern of peripheral blood is indicated for patients who have a rise in temperature, sore throat or signs of any infection during the treatment with Lerivon. Due to the absence of an anticholinergic effect, the drug can be used in patients with prostate adenoma, glaucoma, and gastrointestinal dysfunction, but such patients require observation. Older patients and patients with cardiovascular diseases, as a rule, are well tolerated by Lerivon.In elderly patients, the use of Lerivon usually does not lead to the development of confusion. Patients taking Lerivon should refrain from potentially hazardous activities that require increased attention and quickness of psychomotor reactions (especially in the first few days of therapy).

Drug Interactions

Lerivon does not change the body's response to the on / in the introduction of pressore amines of norepinephrine (norepinephrine) and tyramine. Lerivon does not affect the antihypertensive effects of propranolol (alone or in combination with hydralazine, guanethidine or betanidin). Lerivon does not affect the severity of the hypotensive effect of clonidine and methyldopa, either during one-time or long-term use. No clinically significant interaction of Lerivon with the anticoagulant Fenprocumone was observed. Adverse interaction of Lerivon with MAO inhibitors cannot be ruled out; therefore, the administration of MAO inhibitors should be stopped at least 14 days before the prescription of Lerivon.

Overdosage

When patients received Lerivon in a single dose of 1 g or more (for suicidal purposes), suchthe symptoms, as severe drowsiness, increased blood pressure, in rare cases - arterial hypotension, sinus tachycardia or bradycardia, vomiting, dizziness, ataxia. There were no cases of seizures, arrhythmias, coma.
Treatment: after ingestion of a toxic dose of Lerivon, gastric lavage should be performed for 2 hours, and measures should be taken to maintain the function of the cardiovascular system. Hemodialysis and hemoperfusion are not recommended.

Storage conditions

The drug should be stored in a dry, dark place at a temperature of from 2 ° to 25 ° C.