Buy Imunofan rectal candles 100mkg №5
  • Buy Imunofan rectal candles 100mkg №5

Imunofan rectal candles 100mkg №5

$27.50
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Dosage form

Rectal Candles

Composition

Candles contain: imunofan - 100 mcg.

Excipients: water for injection, Glycine, solid fat, twin 80.

Packaging

In the package 5 pcs.

Mechanism of action

Imunofan has an immunoregulatory, detoxification, hepatoprotective effect and causes inactivation of free radical and peroxide compounds. Pharmacological action is based on the achievement of three main effects: correction of the immune system, restoring the balance of the oxidative-antioxidant reaction of the body and inhibition of multidrug resistance mediated by proteins of the transmembrane cell transport pump.

The action of the drug begins to develop within 2 to 3 hours (fast phase) and lasts up to 4 months (medium and slow phases).

During the fast phase (up to 2–3 days), the detoxification effect is primarily manifested — the antioxidant defense of the body is enhanced by stimulating the production of ceruloplasmin, lactoferrin, and catalase activity; the drug normalizes lipid peroxidation, inhibits the breakdown of cell membrane phospholipids and the synthesis of arachidonic acid, followed by a decrease in blood cholesterol and production of inflammatory mediators.In case of toxic and infectious liver damage, the drug prevents cytolysis, reduces transaminase activity and serum bilirubin level.

During the middle phase (it starts in 2–3 days, the duration is up to 7–10 days), the reactions of phagocytosis and the death of intracellular bacteria and viruses increase.

During the slow phase (it begins to develop on the 7th - 10th day, the duration is up to 4 months), the immunoregulatory effect of Imunofan is manifested - restoration of impaired indicators of cellular and humoral immunity. During this period, normalization of the immunoregulatory index is observed, an increase in the production of specific antibodies is noted. The effect of Imunofan on the production of specific antiviral and antibacterial antibodies is equivalent to the action of some therapeutic vaccines. Unlike the latter, the drug has no significant effect on the production of reagin antibodies of the IgE class and does not enhance the immediate-type hypersensitivity reaction; Imunofan stimulates the formation of IgA in its congenital insufficiency.

In low concentrations (0.01-0.1 mcg / ml) Imunofan effectively suppresses the multidrug resistance of tumor cells and increases their sensitivity to the action of cytostatic drugs.

Indications and usage

Applied in adults and children older than two years for the prevention and treatment of immunodeficiency and toxic conditions, chronic inflammatory diseases of various etiologies.In adults, as an adjuvant for vaccination against bacterial and viral infections.

Contraindications

- Hypersensitivity.
- Pregnancy complicated Rh-conflict.
- Children's age up to 2 years.

Pregnancy and Breastfeeding

Contraindicated in pregnancy, complicated rhesus-conflict.

Dosage and administration

Rectally. Single dose and daily 100 μg (0.1 mg) 1 suppository.

In the treatment of cancer patients in the scheme of radical combined treatment (chemo-radiation therapy and surgery) Once a day, the course of treatment 8 to 10 suppositories before chemo-radiation therapy and surgery, followed by continuing the course during the entire period of treatment.

In patients with a common tumor process (stage III - IV) of various localization in the form of complex or symptomatic therapy. Once, daily, a course of treatment 8 to 10 suppositories, with a break of 15-20 days and a repetition of courses throughout the period of subsequent treatment.

In children with malignant diseases of the hematopoietic and lymphoid tissue 1 time per day, every day, the course of treatment is 10-20 suppositories. The purpose of the drug should be carried out during the entire course of chemo-radiation therapy and after the end of the course to prevent the development of toxicosis.

In the complex therapy of children with papilomatosis of the larynx and oropharynx 1 time per day, daily, the course of treatment is 10 suppositories.

For opportunistic infections (cytomegalovirus and herpes infection, toxoplasmosis, chlamydia, pneumocystosis, cryptosporidiosis) 1 time per day, daily, a course of treatment 15 - 20 suppositories.

In the complex therapy of HIV infection 1 time per day, every day, a course of treatment 15 to 20 suppositories. If necessary, repeat courses should be held in 2-4 weeks.

In chronic viral hepatitis and chronic brucellosis 1 time per day, every day, a course of treatment of 15 to 20 suppositories, repeated courses should be conducted in 2 to 3 months to prevent relapse.

In case of diphtheria 1 time per day, every day, the course of treatment is 8 - 10 suppositories. For diphtheria bacteria - 1 time in 3 days - 3-5 suppositories.

In the treatment of III-IV degree burns with symptoms of toxemia, septicotoxemia, in surgical patients with septic endocarditis, long-term unhealed wounds of the extremities, purulent-septic complications 1 time per day, daily, the course of treatment 7 to 10 suppositories, if necessary, the course of the drug should be continued until 20 suppositories.

In case of broncho-obstructive syndrome, cholecystopancreatitis, rheumatoid arthritis 1 time after 3 days, the course of treatment is 8 - 10 suppositories, if necessary, the course should be continued up to 20 suppositories with the same interval.

In the treatment of psoriasis 1 time per day, every day, a course of treatment 15 to 20 suppositories. In adults, in the scheme of vaccination once a day of vaccination.

Special notes

As a result of the activation of phagocytosis, a short-term exacerbation of the foci of chronic inflammation, supported by the persistence of viral or bacterial antigens, is possible.

Drug Interactions

The effect of Imunofan does not depend on the production of PGE2 and the administration of the drug is possible in combination with anti-inflammatory (steroid and non-steroidal) drugs.

Storage conditions

In a dry, protected from light, out of reach of children at a temperature of from 2 to 8 ° C.