Cytoflavin ampoules in/in 10ml №5

Dosage form

Solution for on / in the introduction.

Composition

1 l of solution for intravenous administration contains: succinic acid 100 g, Riboxin (inosine) 20 g, nicotinamide 10 g, riboflavin mononucleotide (riboflavin) 2 g.
Excipients: N-methylglucamine (meglumine) 165 g, sodium hydroxide 34 g, water for injection.

Packing

In 1 ampoule 10 ml solution. In blister packaging 5 ampoules. In a pack of cardboard 1 pack.

Mechanism of action

Cytoflavin is a metabolic drug. Pharmacological effects are due to the complex effect of the components contained in the preparation Cytoflavin. Stimulates the processes of cellular respiration and energy production, improves the utilization of oxygen by tissues, restores the activity of enzymes that provide antioxidant action.
The drug activates intracellular protein synthesis, promotes the utilization of glucose, fatty acids and GABA resynthesis in neurons through a Roberts shunt. Increases the resistance of the membranes of nerve and glial cells to the effects of ischemia, which is reflected in a decrease in the concentration of neurospecific proteins that characterize the level of destruction of the main structural components of the nervous tissue.
Cytoflavin improves cerebral and coronary blood flow, activates metabolic processes in the central nervous system, reflex disorders, helps restore impaired sensitivity and cognitive-mnestic brain functions.
Positive effect on the parameters of neurological status: reduces the severity of asthenic, cephalgic, vestibular-cerebellar, cochleovestibular syndrome, as well as levels disorders in the emotional-volitional sphere (reduces anxiety, depression). Improves cognitive-mnestic functions and quality of life.
When a / in the introduction contributes to the restoration of disturbed consciousness. It has a quick awakening effect in post-anesthetic depression of consciousness. When using Cytoflavin in the first 12 hours from the onset of stroke, there is a favorable course of ischemic and necrotic processes in the affected area (reduction of the focus), restoration of neurological status and a decrease in the level of disability in the long-term period.

Indications and usage

In adults as part of complex therapy:
- Acute cerebrovascular accident.
- Dyscirculatory (vascular) encephalopathy stage 1-2 and the consequences of cerebral circulation (chronic cerebral ischemia).
- Toxic and hypoxic encephalopathy in acute and chronic poisoning, endotoxicosis, depression of consciousness after anesthesia.
In children, including premature with a gestational age of 28-36 weeks, in complex therapy in the neonatal period:
- With cerebral ischemia.

Contraindications

- Pregnancy.
- Lactation.
- Individual intolerance to the components of the drug.
- It is not assigned to patients (except for the neonatal period) who are in critical condition until central hemodynamic stabilization and / or with a decrease in the partial pressure of oxygen in arterial blood of less than 60 mm. Hg st.
Carefully:
- Nephrolithiasis.
- Gout.
- Hyperuricemia.

Pregnancy and Breastfeeding

Contraindicated.

Dosage and administration

Cytoflavin is administered only in / in a drip in a dilution of 100-200 ml of 5-10% glucose solution or 0.9% sodium chloride solution.
In acute cerebrovascular accident the drug is administered as early as possible from the onset of the development of the disease in a volume of 10 ml per injection with an interval of 8-12 h for 10 days. In the case of severe disease, a single dose is increased to 20 ml.
With dyscirculatory encephalopathy and the consequences of cerebral circulation disorders Cytoflavin is administered in a dose of 10 ml of solution per 1 injection 1 time / day for 10 days.
With toxic and hypoxic encephalopathy the drug is administered in a dose of 10 ml of solution per 1 injection 2 times / day after 8-12 hours for 5 days.
In a coma the drug is administered in a volume of 20 ml for administration at a dilution of 200 ml of glucose solution.
When depression of consciousness after anesthesia the drug is administered once in the same doses.
In the treatment of hypoxic encephalopathy during cardiac surgery using cardiopulmonary bypass injected with 20 ml of the drug in a dilution of 200 ml of 5% dextrose solution for 3 days before surgery, on the day of surgery, 3 days after surgery.
In children (including premature infants) in the neonatal period with cerebral ischemia The daily dose of the drug Cytoflavin is 2 ml / kg / day. The calculated daily dose of the drug is administered intravenously (slowly) after dilution in 5% or 10% dextrose solution (in a ratio of at least 1: 5).
The first injection is the first 12 hours after birth; The best time to start therapy is the first 2 hours of life. It is recommended to inject the prepared solution using an infusion pump at a rate of 1 to 4 ml / hour, ensuring a steady flow of the drug into the bloodstream throughout the day, depending on the estimated daily volume of solutions for basic therapy, the patient's hemodynamic state and indicators of the acid-base state. The course of treatment is on average 5 days.

Adverse reactions

With the rapid in / in the drip are possible: hyperemia of the skin of varying severity, feeling of heat, bitterness and dry mouth, sore throat.
With long-term administration in high doses are possible: transient hypoglycemia, hyperuricemia, exacerbation of gout.
Gastrointestinal: with a / in the introduction rarely - short-term pain and discomfort in the epigastric region, nausea.
Respiratory: with intravenous drip infusion rarely - short-term pain and discomfort in the chest, difficulty breathing, tingling sensation in the nose.
From the side of the central nervous system: when ingestion, transient headache is possible, with intravenous drip infusion it is rare - headache, dizziness.
Allergic reactions: possible pruritus.
Other: with IV drip infusion rarely - dysosmia, blanching of the skin of varying severity.

Special notes

If you have one of the following diseases: nephrolithiasis, gout, hyperuricemia, before taking the drug Cytoflavin you should consult with your doctor. When taking Cytoflavin orally, it may be necessary to adjust the doses of antihypertensive drugs in patients with arterial hypertension.
When taken orally, the drug does not affect the ability to concentrate.
Storage of the solution for intravenous injection in the light is unacceptable! In the formation of sediment use of the drug is prohibited.

Succinic acid, inosine and nicotinamide (active ingredients of the drug Cytoflavin) are compatible with other drugs.
Simultaneous use with antibiotics: with simultaneous use of Cytoflavin, it should be borne in mind that the riboflavin in its composition reduces the activity of Doxycycline, Tetracycline, oxytetracycline, Erythromycin and Lincomycin; incompatible with streptomycin.
Simultaneous use with antidepressants: in case of combined use with Cytoflavin, chlorpromazine, imizine, Amitriptyline, due to the blockade of flavinokinase, violate the inclusion of riboflavin in flavivadine mononucleotide andflavinadenedinucleotide and increase its excretion in the urine.
With simultaneous use of thyroid hormones accelerate riboflavin metabolism.
Simultaneous application with chloramphenicol: when used together, Cytoflavin reduces and prevents the development of side effects of chloramphenicol (impaired hematopoiesis, optic neuritis).
There is no established drug interaction between Cytoflavin and hematopoietic stimulants; antioxidants and anabolic steroids.

Storage conditions

Store in a dry, dark place at a temperature of 18 ° to 20 ° C.

2 years.