Odeston pills 200mg №20

Mechanism of action

Odeston is a choleretic drug. Increases the formation and secretion of bile. It has a selective antispasmodic effect on the bile ducts and the sphincter of Oddi (does not reduce gastrointestinal peristalsis and blood pressure). Reduces stagnation of bile, prevents the crystallization of cholesterol and thereby the development of cholelithiasis.

Pharmacokinetics

When ingested, it is easily absorbed from the digestive tract, weakly bound to plasma proteins. C_max in serum is achieved in 2-3 hours. T_1/2 is about 1 hour. Hymecromone is excreted by the kidneys (about 93% as glucuronate, 1.4% as sulfonate, 0.3% as unchanged).

• biliary dyskinesia and Oddi's sphincter hyperkinetic type;
• non-calculous chronic cholecystitis, cholangitis, cholelithiasis;
• condition after surgery on the gallbladder and biliary tract;
• loss of appetite, nausea, constipation, vomiting (on the background of bile hyposecretion).

Contraindications

• hypersensitivity;
• obstruction of the biliary tract;
• renal / hepatic impairment;
• ulcerative colitis, Crohn's disease;
• peptic ulcer and duodenal ulcer;
• hemophilia;
• children's age up to 18 years.

Pregnancy and Breastfeeding

There are no data on the safety of gimecromone during pregnancy and lactation. Appointment Odestona pregnant and lactation is permissible only in cases where the potential benefit to the mother outweighs the potential risk to the fetus and child.

Composition

1 pill contains:

Active substance: gimecromone 200 mg;

Excipients: potato starch - 45 mg; gelatin - 3 mg; sodium lauryl sulfate - 1 mg; Magnesium stearate - 1 mg;

Dosage and administration

Inside, 30 minutes before meals; adults - 200-400 mg 3 times a day. Daily dose - up to 1200 mg. The course of treatment is 2 weeks. If you miss a dose, you should take the drug as soon as possible, or if the next dose is coming, do not take the missed dose. Do not take a double dose right away.

Adverse reactions

Allergic reactions, diarrhea, flatulence, abdominal pain, mucosal expression, gastrointestinal tract, headache.

Drug Interactions

Morphine weakens the effect of gimecromone.

When taken together with Metoclopramide, the effects of both drugs are weakened.

Enhances the effects of indirect anticoagulants.

At temperatures not above 25 ° C.