Ednit pills 10mg №20

Packaging

In 1 cell contour packaging 10 tablets. In a cardboard bundle 2 packs.

Mechanism of action

Ednit is an ACE inhibitor. Antihypertensive drug. Enalapril maleate is a prodrug: as a result of its hydrolysis, enalaprilat is formed, which inhibits ACE activity, thereby suppressing the formation of angiotensin II. The drug reduces the round neck, increases cardiac output, reduces the end-diastolic pressure in the left ventricle, reduces the pressure in the pulmonary veins and arteries, in the right atrium. With prolonged use, the drug reduces the severity of left ventricular myocardial hypertrophy, prevents the progression of heart failure and slows down the development of left ventricular dilatation. It has some diuretic effect. It lowers intraglomerular hypertension, slowing the development of glomerulosclerosis and the risk of renal failure.

Indications and usage

- Arterial hypertension (including renovascular), both in the form of monotherapy, and in combination with other antihypertensive drugs.
- Chronic heart failure (as part of combination therapy).

Adverse Effects

Cardiovascular: possibly - arterial hypotension (includingorthostatic) collapse; rarely - palpitations, angina, pain in the heart, heart rhythm disturbances.
Nervous system: headache, dizziness, fatigue, drowsiness (2-3%); in some cases, when using the drug in high doses - nervousness, depression, paresthesia, imbalance, tinnitus, decreased visual acuity.
Gastrointestinal: dry mouth, nausea, vomiting, diarrhea, increased activity of hepatic transaminases, increased concentrations of bilirubin in the blood; dyspepsia, pancreatitis; in some cases - a change in taste.
Respiratory: dry cough, shortness of breath, bronchitis, bronchospasm, pneumonia, hoarseness.
Hemic and lymphatic: neutropenia; in patients with autoimmune diseases in some cases - agranulocytosis.
Urogenital: proteinuria.
Fluid and electrolyte balance: hyperkalemia.
Allergic reactions: seldom - rash, urticaria, skin itch; in some cases, angioedema.
Dermatological reactions: in some cases - photosensitivity, hair loss.
Other: sexual disturbances, hot flashes.

Special notes

Caution should be given to the drug for autoimmune diseases, abnormal liver function, loss of fluid and salt, bilateral renal artery stenosis or arterial stenosis of a single kidney, while taking it with immunosuppressants and diuretics.In the case of previous treatment with diuretics (for example, in patients with chronic heart failure), the risk of orthostatic hypotension increases, therefore, before starting treatment with Ednit, it is necessary to compensate for the loss of fluids and salts.
Before examining the function of the parathyroid glands, Ednith should be abolished. Patients taking Ednite should refrain from excessive drinking.

With the simultaneous use of Ednit with NSAIDs may decrease hypotensive action. With the simultaneous use of Ednit and potassium-saving diuretics or potassium preparations, hyperkalemia may develop (when using this combination, it is necessary to control the level of potassium in the blood). Ednit weakens the effect of drugs containing theophylline. Cimetidine lengthens the action of Ednit. With simultaneous use with ethanol, an increase in Ednit's hypotensive effect is noted. With the simultaneous use of Ednit and lithium preparations, a slowdown in the elimination of lithium is observed.

Overdosage

Symptoms: arterial hypotension.
Treatment: the patient should be given a horizontal position with raised legs. In mild cases, a saline solution is prescribed. In more severe cases - in / in the introduction of an isotonic solution of sodium chloride or plasma substitutes. Hemodialysis is possible.

The drug should be stored in a dry, dark place at a temperature of from 15 ° to 30 ° C.

3 years.