Dona pills 750mg №180

Mechanism of action

Dona has an anti-inflammatory and analgesic effect, fills up the endogenous deficiency of Glucosamine, stimulates the synthesis of proteoglycans and hyaluronic acid of synovial fluid; increases the permeability of the joint capsule, restores enzymatic processes in the cells of the synovial membrane and articular cartilage. It promotes sulfur fixation during the synthesis of Chondroitin sulfuric acid, facilitates the normal deposition of Calcium in bone tissue, inhibits the development of degenerative processes in the joints, restores their function, reducing joint pain.

Pharmacokinetics

Suction in the digestive tract - 90%, bioavailability 25%, T_1/2 - 70 hours.

Indications

- Osteoarthritis of the peripheral joints and the spine;

- osteochondrosis.

Dosage and administration

Inside 1 pill 750 mg taken orally, 2 times a day, preferably with meals, with a glass of water. Symptomatic effect occurs 2-3 weeks after the use of the drug. The minimum course of therapy is 4-6 weeks.

If necessary, repeat the treatment with an interval of 2 months. Duration and treatment regimen prescribed by the attending physician.

Side effect

The tolerability of the drug is good, in some cases possible: gastralgia, flatulence, nausea, diarrhea, constipation; headache, drowsiness; allergic reactions - erythema, urticaria, pruritus.

Contraindications

- individual hypersensitivity to the active substance and other components of the drug;

- severe chronic renal failure;

- the period of pregnancy and lactation;

- children's age up to 12 years.

Use during pregnancy and lactation

It is not recommended the appointment of the drug during pregnancy and lactation due to the lack of scientific clinical data in this category of patients.

Application for violations of the liver

When using the drug in patients with severe liver failure, medical supervision is necessary.

Application for violations of kidney function

Contraindicated in severe chronic renal failure. When using the drug in patients with severe renal insufficiency, medical supervision is necessary.

Use in children

Contraindicated in children under 12 years.

Special notes

Precautions for use

Caution should be exercised in patients with allergies to seafood (shrimp, shellfish). The drug contains 75.5 mg of sodium per pill, which should be considered in patients following a controlled sodium diet.

Be wary of taking with bronchial asthma and diabetes.

When using the drug in patients with impaired glucose tolerance, with severe hepatic and renal insufficiency, medical supervision is necessary.

Influence on ability to drive motor transport and control mechanisms

Missing.

Overdosage

Cases of overdose are unknown.

Treatment: gastric lavage, symptomatic therapy.

Drug interaction

Compatible with NSAIDs, Paracetamol and glucocorticosteroids. Increases the absorption of tetracyclines, reduces - semi-synthetic penicillins, chloramphenicol; enhances the effect of coumarin anticoagulants.

Terms and conditions of storage

Store at a temperature not higher than 25 ° С. Keep out of reach of children. Shelf life - 3 years.