
Topiramate reduces the frequency of action potentials that are characteristic of a neuron in a state of persistent depolarization, which indicates the dependence of the blocking effect of the drug on sodium channels on the state of the neuron. This active substance potentiates the activity of GABA against certain subtypes of GABA receptors (including GABAA receptors), modulates the activity of the GABAA receptors themselves, and also inhibits the activation of kainate / AMPK receptors for glutamate by the kainate and does not affect N activity methyl D-aspartate in relation to NMDA receptors.