Adaklin cream 0.1% 30g

Dosage Forms

cream for external use 0.1%

Group

Dermatoprotective agents

Active ingredient

International non-proprietary name

Adapalen

Pharmacology

The drug is for external use. Adapalen is a retinoid metabolite, has comedonoliticheskoe and anti-inflammatory action, normalizes the processes of keratinization and epidermal differentiation. The mechanism of action of adapalene is based on the interaction with specific gamma receptors of epidermal skin cells. As a result of the action of adapalene, in particular, there is a decrease in the “cohesion” of epithelial cells in the mouth of the hair-tissue follicle and a decrease in the prerequisites for the formation of microcomedo. Adapalen has an anti-inflammatory effect in vitro and in vivo by acting on inflammation factors by inhibiting leukocyte migration in the focus of inflammation and arachidonic acid metabolism. Absorption: adapalene absorption through the skin is very low (about 4% of the dose used). Excretion: removal of adapalena from the body occurs mainly with bile.

Indications

Acne.

Contraindications

Pregnancy; lactation period (breastfeeding); hypersensitivity to the components of the drug; children's age under 12 years old. With caution: the drug should be used with caution in dermatitis, eczema, seborrhea. during lactation (breastfeeding).

Adverse Effects

Dermatological reactions: skin irritation, hyperemia and peeling of the skin at the site of application (treatment should be stopped until the skin irritation disappears or the frequency of application is reduced).

Interaction

Since adapalen does not interact with oxygen and is not destroyed by light, it is possible to simultaneously treat acne with drugs such as Clindamycin or benzoyl peroxide.

Dosing and Administration

Outwardly. Before applying the cream must be cleaned and dried skin. With a light touch, apply the cream evenly on the affected surface 1 time per day in front of the skin, avoiding contact with the mucous membranes of the eyes and lips. The therapeutic effect develops after 4-8 weeks of treatment, persistent improvement occurs after 3 months of treatment. In some cases, due to short-term irritation of the skin, treatment may be suspended until the signs of irritation disappear. Repeated treatment is possible after consultation with the doctor.

Overdosage

An overdose of the drug is unlikely.

Special notes

In case of accidental contact with the mucous membranes of the eyes, mouth or nose, rinse thoroughly with warm water. Avoid direct sunlight as skin irritation may occur. Treatment can be continued if sun exposure is minimized through the use of sunglasses and a hat. It is not recommended to use cosmetics with a drying and irritating effect on the skin at the same time (for example, perfume or ethanol-containing agents). drugs for the treatment of acne, used in the morning.

Storage conditions

Keep out of reach of children at a temperature not higher than 25 C.

Vacation order

Over-the-counter