Vizarsin Q-Tab pills dispersible 50mg №4

Treatment of erectile dysfunction, characterized by the inability to achieve or maintain an erection of the penis, sufficient for satisfactory sexual intercourse.

Pulmonary hypertension.

Dosage and administration

Treatment of erectile dysfunction: take Varsarsin inside about 1 hour before planned sexual activity. A single dose is 50 mg. Given the efficacy and tolerability, the dose may be increased to 100 mg or reduced to 25 mg. Maximum single dose makes 100 mg. The maximum frequency of use is 1 time / day. For elderly patients over the age of 65 years and with concomitant violations of renal or liver function, the dose is 25 mg.

Pulmonary hypertension: by mouth 20 mg 3 times / day with an interval of about 6-8 hours, regardless of the meal. Maximum Daily Dose makes 60 mg. Patients with impaired renal function dose adjustment is not required, but in case of poor tolerance the dose is reduced to 20 mg 2 times / day.

Side effect

From the side of the central nervous system: possible headache, hot flashes, dizziness, insomnia.

Gastrointestinal: possible dyspepsia, asthenia, diarrhea, abdominal pain, nausea.

Musculoskeletal system: arthralgia, myalgia, increased muscle tone.

Respiratory: nasal congestion, pharyngitis, rhinitis, sinusitis, respiratory infections, respiratory failure.

Special senses: a change in vision (light and transient; mainly a change in the color of objects, as well as enhanced perception of light and impaired visual clarity), conjunctivitis.

Other: possible flu-like syndrome, the development of infectious diseases, symptoms of vasodilation, back pain, rash, urinary tract infections, dysfunction of the prostate gland; in isolated cases - priapism.

Contraindications

Simultaneous intake of donators of nitric oxide or nitrates in any form, hypersensitivity to Sildenafil.

Application for violations of the liver

With abnormal liver function, the dose is 25 mg.

Application for violations of kidney function

In case of impaired renal function, the dose is 25 mg.

Use in children

Sildenafil is not used in patients under the age of 18 years.

Use in elderly patients

For elderly patients over the age of 65, the dose is 25 mg.

Special notes

Before starting sildenafil to treat erectile dysfunction, a cardiovascular system should be examined.

Care should be taken Vizarsin Q-Tab in patients with anatomical deformation of the penis (eg, angulation, cavernous fibrosis or Peyronie's disease) and people with diseases that predispose to the development of priapism (such as sickle cell anemia, multiple myeloma or leukemia).

Do not use Vizarsin Q-Tab in patients for whom sexual activity is undesirable.

Use with caution in patients with a tendency to bleeding, with gastric ulcer and duodenal ulcer in the acute phase, with hereditary pigmentary retinitis.

Sildenafil is not used in patients under the age of 18 years.

Influence on ability to drive motor transport and control mechanisms

Sildenafil does not affect the ability to drive vehicles and control mechanisms.

Drug interaction

With the simultaneous use of CYP3A4 inhibitors (erythromycin, cimetidine), the clearance of sildenafil decreases, the concentration of sildenafil in the blood plasma increases.

With simultaneous use of indinavir, saquinavir, ritonavir increases C_max in plasma and AUC of sildenafil, which is due to inhibition of CYP3A4 isoenzyme under the influence of indinavir, saquinavir, ritonavir.

Stronger CYP3A4 isoenzyme inhibitors, such as Ketoconazole or itraconazole, can be expected to increase plasma concentration of sildenafil

With simultaneous use with nitrates, the hypotensive effect of nitrates is enhanced.

A case of developing symptoms of rhabdomyolysis after a single dose of sildenafil in a patient receiving Simvastatin is described.