Bitsillin-5 1500 units bottle №1

Mechanism of action

An antibiotic of the penicillin group destroyed by penicillinase. The basis of the mechanism of action is a violation of the synthesis of peptidoglycan - the mucopeptide of the cell wall, which leads to inhibition of the synthesis of the cell wall of the microorganism, suppressing the growth and reproduction of bacteria.
Active against Gram-positive bacteria (Staphylococcus spp., Streptococcus spp. / including Streptococcus pneumoniae /).
To drug are resistant viruses, rickettsia, fungi, protozoa, most gram-negative bacteria.
The drug has a prolonged effect.

With the introduction of Bicillin-5, a high concentration is created in the first hours after injection.
After the administration of Bicillin-5 at a dose of 1.2-1.5 million units in children and adults, a therapeutic concentration of 0.3 U / ml is reached, which persists for 28 days.

Indications and usage

- treatment of infectious diseases caused by pathogens that are sensitive to penicillin (especially in cases where it is necessary to create a long-term therapeutic concentration in the blood);
- year-round prevention of rheumatism in adults and children.

Do not allow more frequent administration of the drug than indicated in the dosing regimen.
For adults the drug is prescribed in a dose of 1.5 million. IU 1 time in 4 weeks.
Pre-school children the drug is prescribed in a dose of 600 000 IU once every 3 weeks, children over 8 years old 1.2-1.5 million. IU 1 time in 4 weeks.
Rules for the preparation and administration of the solution
Suspension Bicillin-5 is prepared immediately before use. In a bottle with the drug injected 5-6 ml of sterile water for injection, 0.9% sodium chloride solution or 0.25-0.5% solution of Novocaine. The mixture in the vial is stirred (between the palms) until a homogeneous suspension (or suspension) is formed, which is injected immediately deep into the upper outer quadrant of the buttock. Rubbing the buttocks after the injection is not recommended.

Adverse reactions

Allergic reactions: headache, fever, urticaria, rash on the skin and mucous membranes, arthralgia, eosinophilia, angioedema. Cases of anaphylactic shock with a fatal outcome are described.
Local reactions: possible pain at the injection site.

Contraindications

- bronchial asthma;
- urticaria;
- hay fever;
- hypersensitivity to penicillins, sulfonamides.

Pregnancy and breastfeeding

Data on the use of Bicillin-5 during pregnancy and lactation (breastfeeding) is not provided.

Bicillin-5 can be used only in cases when it is known that the patient has no hypersensitivity reactions to penicillin, since the drug provides a constant flow of penicillin into the blood for a long time.
Patients who have had unusual reactions to the drug should be under constant medical supervision until the side effects disappear completely. In severe cases, appropriate therapy is prescribed (atropine 0.1% 0.5-0.6 ml, epinephrine 0.1% 1 ml, ephedrine 5% 1 ml, caffeine sodium benzoate 10%, ammonia).

Overdosage

Currently, cases of drug overdose Bicillin-5 were reported.

Drug Interactions

Drug interaction drug Bicillin-5 is not described.

Storage conditions

List B. The drug should be stored in a dry cool place at a temperature not exceeding 20 ° C. Shelf life - 3 years.