Cavinton Forte pills 10mg №90

Dosage form

Pills

Composition

1 pill contains: Vinpocetine 10 mg

Excipients: Magnesium stearate, colloidal silicon dioxide, talc, lactose monohydrate, corn starch

Packaging

In the blister 15 tablets. In a cardboard box 6 blisters.

Mechanism of action

Cavinton Forte - a drug that improves cerebral circulation. It improves brain metabolism by increasing the consumption of glucose and oxygen by the brain tissue. Increases the resistance of neurons to hypoxia, enhancing glucose transport to the brain through the BBB; translates the breakdown of glucose into an energetically more economical aerobic pathway; selectively blocks Ca 2+ -dependent phosphodiesterase (PDE); increases levels of AMP and cGMP brain. Increases ATP concentration and ATP / AMP ratio in brain tissues; enhances the metabolism of norepinephrine and brain serotonin; stimulates the ascending branch of the noradrenergic system, has an antioxidant effect.

Reduces platelet aggregation and increased blood viscosity; increases the deforming ability of erythrocytes and blocks the utilization of adenosine by erythrocytes; contributes to increased oxygen return by red blood cells. Enhances the neuroprotective effect of adenosine.

Increases cerebral blood flow; reduces the resistance of cerebral vessels without significant changes in systemic circulation (BP, minute volume, heart rate, OPS). Not only does not have the effect of "robbing", but also increases the blood supply primarily in ischemic brain regions with low perfusion.

Indications and usage

- To reduce the severity of neurological and mental symptoms in various forms of circulatory insufficiency of the brain, including:
- Condition after ischemic stroke.
- The recovery stage of hemorrhagic stroke.
- Consequences of a stroke.
- Transient ischemic attack.
- Vascular dementia.
- Vertebrobasilar insufficiency.
- Atherosclerosis of cerebral vessels.
- Post-traumatic and hypertensive encephalopathy.

- Perceptual hearing loss.
- Diseases of Meniere.
- Idiopathic tinnitus.

Contraindications

- Acute phase of hemorrhagic stroke.
- Severe form of CHD.
- Severe arrhythmias.
- Pregnancy.
- Lactation (breastfeeding).
- Children's age up to 18 years.
- Hypersensitivity to vinpocetine or other components of the drug.

Pregnancy and Breastfeeding

Cavinton Forte is contraindicated for use during pregnancy, because Vinpocetine crosses the placental barrier. Moreover, its concentration in the placenta and in the blood of the fetus is lower than in the blood of the pregnant woman. When taken in high doses, placental bleeding and spontaneous abortions may develop, probably as a result of increased placental blood supply.

Within 1 hour, 0.25% of the administered dose is excreted in breast milk. If necessary, the use of the drug during lactation should stop breastfeeding.

Dosage and administration

The duration of the course of treatment and the dose are determined individually.

The average daily dose is 15-30 mg (5-10 mg 3 times / day). The initial daily dose is 15 mg. The maximum daily dose is 30 mg.

The therapeutic effect develops approximately in a week from the beginning of taking the drug. It takes three months to achieve the full therapeutic effect.

When violations of the kidneys and liver correction dosing regimen is not required, the lack of cumulation allows for long courses of treatment.

Adverse reactions

Cardiovascular: ECG changes (ST depression, prolongation of the QT interval); tachycardia, extrasystole (however, the presence of a causal connection has not been proven because in the natural population these symptoms are observed with the same frequency); lability of blood pressure, tidal sensation.

On the part of the central nervous system: Sleep disturbances (insomnia, increased sleepiness), dizziness, headache, general weakness (these symptoms may be manifestations of the underlying disease), increased sweating.

On the part of the digestive system: Dry mouth, nausea, heartburn.

Allergic reactions: Skin rash, urticaria.

Drug interactions

No interaction was observed with simultaneous use with beta-blockers (chloranolol, pindolol), clopamide, glibenclamide, Digoxin, acenocoumarol and hydrochlorothiazide, imipramine.

The simultaneous use of the drug Cavinton Forte and methyldopa sometimes caused some enhancement of the hypotensive effect, therefore, using this combination requires regular monitoring of blood pressure.

Despite the lack of data confirming the possibility of interaction, it is recommended that caution be exercised while simultaneously prescribing Cavinton Forte with centrally acting drugs, antiarrhythmics and anticoagulants.

Store in a dark place at a temperature of 15 ° to 30 ° C.

5 years.