Cefotaxime powder for injection 1000mg bottle №1

Active ingredient

Cefotaxime - it is a powder from white to pale yellow color, freely soluble in water, practically insoluble in organic solvents. Molecular weight is 447.46. The half-life is 1.1 hours.
Each vial contains Cefotaxime Sodium 500 mg and 1.0 g;
1 bottle per pack.

Pharmacology

Cefotaxime is a third generation cefagosporin antibiotic for parenteral use. Bactericidal effect. Possesses a wide range of antimicrobial action.
Highly active against gram-negative microorganisms resistant to other antibiotics: E.coli, Citobacter, Proteus mirobilis, Proteus indole, Ptovidencia, Klebsiella, Serratia, some strains of Pseudomonas, Haemophlus influenzae. Less active against gram-positive cocci, mainly staphylococci. The drug is highly resistant to beta-lactamases of gram-negative bacteria..

Apply Cefotaxime with infections caused by microorganisms susceptible to it (mainly gram-negative); infections of the respiratory and urinary tract, kidneys; infections of the ear, throat, nose, septicemia, endocarditis, meningitis; infections of bones and soft tissues, abdominal cavity; with gynecological infectious diseases, gonorrhea; wound and burn infections and others.

Contraindications

The drug is contraindicated in case of hypersensitivity to cephalosporin antibiotics.
Cross-allergy between penicillins and cephalosporins is possible.
Caution is needed in the appointment of the drug to patients with impaired renal function and liver.
In children under 2.5 years of age, intramuscular administration of the drug cannot be used.

Dosage and administration

Apply Cefotaxime intramuscularly and intravenously.
For intramuscular injection dissolve 0.5 g of the drug in 2 ml (respectively 1 g in 4 ml) of sterile water for injection. Injected deep into the gluteus muscle. As a solvent for intramuscular administration, 1% Lidocaine is also used (for 0.5 g-2 ml, for 1 g - 4 ml).
For intravenous administration 0.5-1 g of cefotaxime are dissolved in 4 ml (2 g-10 ml) of sterile water for injection. Slowly enter over 3-5 minutes.
For drip (within 50-60 minutes) dissolve 2 g of the drug in 100 ml of isotonic sodium chloride solution or 5% glucose solution.

The usual dose of cefotaxime for adults and children over 12 is 1 g every 12 hours. In severe cases, the dose is increased to 3 or 4 grams per day, the drug is administered 3 or 4 times 1 g. The maximum daily dose, depending on the severity of the disease, may be increased to 12 g.
The usual dose for newborns and young children is 50-100 mg / kg body weight per day with intervals of introduction from 6 to 12 hours. For premature babies, the daily dose should not exceed 50 mg / kg.
In case of impaired renal function, the dose is reduced. With creatinine clearance of 10 ml / min and less than the daily dose of the drug is halved.

Drug interactions

With simultaneous use of Cefotaxime with potentially nephrotoxic drugs (aminoglycoside antibiotics, furosemide), it is necessary to monitor renal function (danger of nephrotoxic action of the latter).
Detection of a false-positive Coombs test is possible.
In the determination of sugar in the urine by the neo-equilibrium method (for example, the Benedict method), false-positive results are possible. Cefotaxime solutions are incompatible with solutions of other antibiotics with an aqueous syringe or dropper.

Adverse reactions

When using cefotaxime, allergic reactions are possible (skin rashes, fever, anaphylactic shock), indigestion (dyspeptic phenomena, pseudomembranous colitis (rarely), impaired liver function tests), an increase in the number of rosinophils, leukopenia, neutropenia, agranulocytosis, hemolytic anemia, anemonemia, anemia. phosphatase and nitrogen content in the urine. Pain, redness and swelling at the injection site. May increase body temperature.

Storage conditions

Store at temperatures up to 25 ° С in a dry, dark place, out of reach of children!
Shelf life - 2 years.