Semax nose drops 0.1% 3ml

Composition

Semax 0,1% intranasal solution:
1 ml of solution contains heptapeptide 1 mg, nipagina (para-hydroxybenzoic acid methyl ester) 1 mg and purified water;
1 bottle with 3 ml of solution contains heptapeptide - 3 mg;
1 drop of solution contains 50 mcg of heptapeptide;
0.1% solution in vials of 3 ml with a stopper-pipette.

nasal drops 1%:
1 ml of the solution contains heptapeptide - 10 mg, nipagin (para-hydroxybenzoic acid methyl ester) - 1 mg as a preservative and purified water;
1 bottle with 3 ml of solution contains heptapeptide - 30 mg;
1 drop of solution for intranasal use contains 500 mcg of heptapeptide;
1% solution in 3 ml vials with a stopper-pipette.
The number of doses in one package is 15 (when calculating a single dose of 2000 mcg).

Pharmacology

Semax - a nootropic agent. The original synthetic peptide drug, which is an analogue of a fragment of adrenocorticotropic hormone (ACTH_4-10) (methionyl-glutamyl-histidyl-phenylalanyl-prolyl-glycyl-proline), completely devoid of hormonal activity.
All amino acids L - forms.

Semax affects the processes associated with the formation of memory and learning, enhances selective attention when learning and analyzing information, improves mnestic functions; improves the body's adaptation to hypoxia, cerebral ischemia, anesthesia and other damaging effects.In the context of neuropsychic fatigue, Semax facilitates concentration of attention, improves operator activity, contributes to the preservation and accelerates the restoration of mental performance.

Semax improves the brain's energy processes, increasing its resistance to stress damage and hypoxia.

Indications and usage

Semax 0.1%
Intellectual and mental disorders in vascular lesions of the brain, conditions after traumatic brain injury and neurosurgical operations; for the prevention and treatment of post-narcotic disorders, as well as astheno-neurotic disorders of various origins, including after ionizing radiation. To increase the adaptive capacity of the human body in extreme situations, prevent mental fatigue during monotonous operator activity during the most intense periods of work in emergency conditions.

In ophthalmology Semax is used in atrophy of the optic nerve, neuritis inflammatory, toxic-allergic etiology.

In pediatrics: as a nootropic agent in children aged 5 to 14 years in the treatment of minimal brain dysfunctions (including ADHD - attention deficit hyperactivity disorder).

Treatment of the acute period of ischemic stroke.

Contraindications

Acute psychotic states, disorders accompanied by anxiety, pregnancy, breastfeeding, diseases of the endocrine system. Hypersensitivity to the drug. This dosage does not apply in children under 5 years.

Dosage and administration

Semax is administered intranasally. One drop of the standard solution contains 50 μg of the active substance. A pipette solution of the drug in an amount of not more than 2-3 drops is injected into each nasal passage. If you need to increase the dosage of the introduction is carried out in several stages at intervals of 10 - 15 minutes.
The single dose is 200 - 2000 mcg (at the rate of 3 - 30 mcg / kg).
Daily dose of 500-5000 mg (at the rate of 7-70 mg / kg).
The drug is prescribed daily for 3 to 5 days, if necessary, the course of treatment is extended to 14 days.
With diseases of the optic nerve The drug is buried 2-3 drops in each nasal passage 2-3 times a day. Daily dose of 600-900 mg / day. The course of treatment is 7-10 days. In addition, the drug can be administered by endonasal electrophoresis. The drug is injected from the anode. Current 1 mA, duration of exposure 8 -12-15 minutes.
Daily dose of 400-600 mg / day. The course of treatment is 7-10 days.
Children:
With minimal brain dysfunction The preparation is packed with 1-2 drops in each nasal passage 2 times a day (in the morning and in the afternoon). Daily dose of 200-400 mg / day. The course of treatment is 30 days.

Semax is administered intranasally using a dropper bottle. The volume of one drop is 0.05 ml (50 μl). One drop of the standard solution contains 500 μg of the active substance.
With a stroke of moderate severity 2-3 drops are added to each nostril at a time, which is 2000 μg (4 drops or 0.2 ml) - 3000 μg (6 drops or 0.3 ml). Instillation is carried out 3-4 times a day, with an interval of 3-4 hours between instillations.The daily dose is 6000 mcg (12 drops or 0.6 ml) - 12000 mcg (24 drops or 1.2 ml).
In severe stroke at one time, 3-4 drops are injected into each nostril, which is 3000 mcg (6 drops or 0.3 ml) - 4000 mcg (8 drops or 0.4 ml). Instillation is carried out 4-5 times a day with an interval between instillations of 2.5-3 hours. The daily dose is 12,000 mcg (24 drops or 1.2 ml) - 20,000 mcg (40 drops or 2.0 ml).
The drug is prescribed daily for 10 days.

Drug interactions

Given the way of administration of Semax (intranasal), it is undesirable to administer agents with local vasoconstrictor action when administered intranasally.

Adverse reactions

Excitement, insomnia.

List B. In the dark place at +8 - + 10 ° C, in places inaccessible to children. Not flammable.

- 2 years.