Cortexin lyophilisate for the preparation of a solution of 5 mg №10

Mechanism of action

Nootropic drug.

Contains a complex of low molecular weight water-soluble polypeptide fractions with a molecular weight of not more than 10,000 Da. It penetrates the BBB directly to the nerve cells. The drug has a nootropic, neuroprotective, antioxidant and tissue-specific effect.

Nootropic action

Improves higher brain functions, learning and memory, concentration, resistance to various stress effects.

Neuroprotective action

It protects neurons from damage by various endogenous neurotoxic factors (glutamate, Calcium ions, free radicals), reduces the toxic effects of psychotropic substances.

Antioxidant action

Inhibits lipid peroxidation in neurons, increases neuron survival under conditions of oxidative stress and hypoxia.

Tissue-specific action

It activates the metabolism of neurons of the central and peripheral nervous system, reparative processes, improves the function of the cerebral cortex and the overall tone of the nervous system.

Mechanism of action

The mechanism of action of the drug Cortexin^® due to the activation of neuronal peptides and brain neurotrophic factors; optimizing the balance of metabolism of excitatory and inhibitory amino acids, dopamine, serotonin; GABA-ergic effect; a decrease in the level of paroxysmal convulsive activity of the brain, the ability to improve its bioelectric activity; preventing the formation of free radicals (lipid peroxidation products).

Pharmacokinetics

The composition of the drug Cortexin^®whose active ingredient is a complex of polypeptide fractions, does not allow the usual pharmacokinetic analysis of individual components.

Indications

In the complex therapy of the following conditions and diseases:

- disorders of cerebral circulation;

- traumatic brain injury and its consequences;

- encephalopathy of various origins;

- cognitive impairment (memory and thinking disorders);

- acute and chronic encephalitis and encephalomyelitis;

- epilepsy;

- asthenic conditions;

- suprasegmental vegetative disorders;

- reduced learning ability;

- delayed psychomotor and speech development in children;

- various forms of cerebral palsy.

Dosage and administration

The drug is administered in / m.

Before injection, the contents of the vial are dissolved in 1-2 ml of a 0.5% solution of procaine (novocaine), water for injection or 0.9% sodium chloride solution, directing the needle to the wall of the vial to avoid foaming, and injected once daily: for adults at a dose of 10 mg for 10 days; children weighing up to 20 kg at a dose of 0.5 mg / kg, with body weight more than 20 kg - at a dose of 10 mg for 10 days. If necessary, repeat the course after 3-6 months.

At hemispheric ischemic stroke in acute and early recovery periods for adults the drug is administered at a dose of 10 mg 2 times / day (morning and afternoon) for 10 days, with a repeated course after 10 days.

Side effect

No adverse events reported. Individual hypersensitivity to the drug components is possible.

Contraindications

- Individual intolerance to the drug.

Use during pregnancy and lactation

The drug is contraindicated for use in pregnancy (due to lack of data from clinical studies).

If necessary, the appointment of the drug during lactation should stop breastfeeding (due to lack of data from clinical studies).

Use in children

The use is possible according to the dosing regimen.

Special notes

Cortexin^® should be used only in accordance with the prescription of a doctor.

The dissolved drug vial cannot be stored and used after storage. Cortexin solution^® It is not recommended to mix with other solutions.

Features of the drug at the first injection or with its cancellation are absent.

In the case of skipping the injection, it is not recommended to inject a double dose, but to conduct the next injection as usual on the scheduled day.

Special precautions when destroying unused drugs are not required.

Influence on ability to drive motor transport and control mechanisms

The use of the drug does not affect the performance of potentially hazardous activities that require special attention and quick reactions (driving, working with moving machinery).

Overdosage

Currently, no cases of overdose have been reported.

Drug interaction

Drug interaction of the drug Cortexin^® not described.

Terms and conditions of storage

The drug should be stored out of the reach of children, protected from light at a temperature of 2 ° to 20 ° C. Shelf life - 3 years.