Diuver pills 10mg №60

Indications and usage

Edema caused by heart failure, liver, kidney and lung diseases.

Contraindications

- Hepatic coma and precomatose state.
- Renal failure with increasing azotemia.
- Arterial hypotension.
- Arrhythmias.
- Pregnancy.
- Lactation period (no data on the use of the drug during lactation).
- Age up to 18 years (efficacy and safety have not been established).
- Anuria.
- Hypersensitivity to Torsemide and sulfonamides.
Precautions should be prescribed to patients with a predisposition to hyperuricemia, gout, with latent and severe diabetes.

Pregnancy and Breastfeeding

The drug is contraindicated for use during pregnancy and lactation.

Tablets are taken 1 time / day after meals.
The average therapeutic dose is 5 mg / day. If necessary, you can increase the dose to 20 mg / day, and in some cases - up to 40 mg / day.
Patients of advanced age do not require special selection of a dose.

Special notes

Prior to the appointment of Diuvera, water-electrolyte balance should be corrected. Be careful when taking gout or a tendency to increase uric acid levels.With long-term treatment with Diuver, it is recommended that the electrolyte balance, glucose, uric acid, creatinine and blood lipids be monitored.
Patients with diabetes mellitus type 1 or 2 should regularly monitor blood glucose levels.
During the treatment period, patients should avoid driving vehicles and other activities that require high concentration of attention and speed of psychomotor reactions.

Drug Interactions

When combined, Torsemide increases the sensitivity of the myocardium to cardiac glycosides (due to the possible development of hypokalemia and hypomagnesemia).
With simultaneous use of Torsemide with mineral and glucocorticoids, laxatives can increase the excretion of potassium.
With simultaneous use of Torsemide enhances the action of antihypertensive drugs.
When combined with the use of Torsemide, especially in high doses, it can enhance the nephro and ototoxic effects of aminoglycoside antibiotics, the toxicity of Cisplatin, the nephrotoxic effects of cephalosporins, and the cardio and neurotoxic effects of lithium preparations.
When used together, Torsemide may enhance the effects of peripheral muscle relaxants (coumarin derivatives) and theophylline.
With the simultaneous use of Torsemide with salicylates (in high doses), their toxic effect may be enhanced.
When used together, Torsemide may reduce the effectiveness of hypoglycemic (antidiabetic) agents.
With the consequent or simultaneous taking of Torsemide with ACE inhibitors, a transient drop in blood pressure is possible. If you need to use such a combination, you should either reduce the initial dose of the ACE inhibitor, or reduce the dose of Torsemide (or temporarily cancel it).
When used together, NSAIDs and probenecid may reduce the diuretic and hypotensive effects of Torsemide.
Kolestiramin can reduce the absorption of Torsemide from the gastrointestinal tract (according to preclinical studies in animals).

Overdosage

Symptoms: perhaps - forced urination, accompanied by hypovolemia, electrolyte imbalance, followed by a fall in blood pressure, drowsiness and confusion, collapse. Disorders from the gastrointestinal tract may be observed.
Treatment: dose reduction or drug withdrawal; simultaneous replacement of fluid and electrolyte losses. There is no specific antidote.

The drug should be stored at a temperature not higher than 30 ° C.