Elkar ampoules 100mg/ml 5ml №10

Packaging

10 vials of 5 ml.

Mechanism of action

Elkar - a drug for the correction of metabolic processes.
L-carnitine is a natural substance related to Vitamins of group B. It participates in metabolic processes as a carrier of fatty acids (including palmitic) through cell membranes from the cytoplasm to the mitochondria, where these acids are oxidized (beta-oxidation process) to form large amounts of metabolic energy (in the form of ATP).
The drug increases the resistance of nervous tissue to damaging factors (hypoxia, trauma, intoxication, etc.), inhibits the formation of ketoacids and anaerobic glycolysis, reduces the degree of lactic acidosis. The drug replenishes the alkaline reserve of the blood, helps restore cerebral hemodynamic autoregulation and increases the blood supply to the affected area, accelerates the reparative processes in the lesion and has an anabolic effect.

Indications and usage

Elkar is used as part of complex therapy in acute hypoxic states (acute brain hypoxia, ischemic stroke, transient ischemic attack). The drug is prescribed in the acute, subacute and recovery periods of disorders of cerebral circulation. Applied with dyscirculatory encephalopathy and various traumatic and toxic brain lesions, in the recovery period after surgical interventions. Elkar is indicated for primary and secondary Carnitine deficiency, including in patients with chronic renal failure on hemodialysis; with cardiomyopathy, ischemic heart disease (angina pectoris, acute myocardial infarction, post-infarction conditions), hypoperfusion due to cardiogenic shock and other metabolic disorders in the myocardium.

Contraindications

Individual intolerance, pregnancy, lactation (currently there are no data on the possibility and safety of the drug during pregnancy and lactation).

Dosage and administration

Elkar is administered intravenously, slowly or intravenously (2-3 minutes) or intramuscularly. Before the on / in the introduction of the contents of the ampoule is dissolved in 100-200 ml of solvent (0.9% sodium chloride solution or 5% dextrose (glucose)).
In acute disorders of cerebral circulation, 1 g / day is prescribed for 3 days, and then 0.5 g / day for 7 days. After 10-12 days, repeated courses are possible within 3-5 days.
When prescribing the drug in the subacute and recovery period, with dyscirculatory encephalopathy and various brain lesions, carnitine deficiency, patients are given an Elcar solution at the rate of 0.5-1 g / day intravenously (drip, stream) or intramuscularly (2-3 times day) without breeding for 3-7 days. If necessary, after 12-14 days appoint a second course.
Intravenous administration, slowly (2-3min.) Administered with secondary carnitine deficiency with hemodialysis - 2 g once (after the procedure); in acute myocardial infarction, acute heart failure - 3-5 g / day, divided into 2-3 doses in the first 2-3 days with a subsequent dose reduction by 2 times; in case of cardiogenic shock - 3-5 g / day, divided into 2-3 doses before the patient leaves the shock. Then go on oral Elkar.

Adverse reactions

Allergic reactions, muscle weakness (in patients with uremia) are possible.
With the rapid introduction (80 drops / min or more) may cause pain along the vein, passing with a decrease in the rate of administration.

Treatment of children under the age of 3 years under the supervision of a physician.
Influence on ability to drive motor transport and control mechanisms: the drug does not affect the performance of potentially hazardous activities that require special attention and quick reactions (driving and other vehicles, working with moving machinery, the work of the dispatcher and operator, etc.)

Drug Interactions

Glucocorticosteroids contribute to the accumulation of the drug in the tissues (except the liver), other anabolics enhance the effect.

Overdosage

Symptoms: dyspeptic disorders, myasthenic disorders (in patients with uremia).
Treatment: gastric lavage, reception of Activated carbon.

Storage conditions

The drug should be stored in a dark place, out of the reach of children, at a temperature of 15 ° to 25 ° C.