Flebaven pills 500mg №32

The composition of 1 tablet

Core:

Purified micronized flavonoid fraction, substance - granules 613.00 mg

[The active substance of the substance - granules:

Purified micronized flavonoid fraction¹ 500.00 mg

Auxiliary substances of the substance - granules:

Microcrystalline cellulose 82.00 mg, povidone K-30 31.00 mg]

Excipients:

Sodium carboxymethyl starch 27.00 mg, talc 6.00 mg, Magnesium stearate 4.00 mg

Shell film:

Opadray orange 03Н32599² 18.00 mg

¹ Purified micronized flavonoid fraction contains 90% (450 mg) of diosmin and 10% (50 mg) of other flavonoids in terms of hesperidin.

² Opadray orange 03Н32599 contains:

hypromellose 71.714%, titanium dioxide (E171) 15.936%, talc 6.972%, propylene glycol 4.980%, iron dye yellow oxide (E172) 0.332%, iron dye red oxide (E172) 0.066%

Indications for use

• Treatment of symptoms of venous lymphatic insufficiency:

- feeling of heaviness in the legs;

- pain;

- "tired" legs.

• Symptomatic therapy of acute hemorrhoids.

Contraindications

• Hypersensitivity to active or to the excipients which are a part of a preparation.
• It is not recommended to take the drug during breastfeeding.

Use during pregnancy and during breastfeeding

Pregnancy

Animal experiments revealed no teratogenic effects.

To date, there have been no reports of any side effects when using the drug in pregnant women.

Breastfeeding period

Due to the lack of data on the removal of the drug in breast milk, women during breastfeeding is not recommended to take the drug.

Dosage and administration

Inside

The recommended dose for venous lymphatic insufficiency is 2 pills per day:

1 pill - in the middle of the day and 1 pill - in the evening, during the meal.

The duration of the course of treatment can be several months (up to 12 months). In the case of recurrence of symptoms, according to the recommendation of the doctor, the treatment can be repeated.

The recommended dose for acute hemorrhoids is 6 pills per day: 3 pills in the morning and

3 pills in the evening for 4 days, then 4 pills per day: 2 pills in the morning and 2 pills in the evening over the next 3 days.

Side effect

The classification of the incidence of side effects recommended by the World Health Organization (WHO):

very often ≥ 1/10

often from ≥ 1/100 to <1/10

infrequently from ≥ 1/1000 to <1/100

rarely from ≥ 1/10000 to <1/1000

very rarely <1/10000

frequency unknown cannot be estimated based on available data.

From the side of the central nervous system:

seldom: dizziness, headache, general malaise.

Gastrointestinal:

often: diarrhea, dyspepsia, nausea, vomiting.

infrequently: colitis.

frequency unknown: abdominal pain.

From the skin:

rarely: skin rash, pruritus, urticaria.

frequency unknown: isolated swelling of the face, lips, eyelids. In exceptional cases, angioedema.

INFORM THE DOCTOR ABOUT THE APPEARANCE OF ANY ANYTHING IN YOU, NOT INCLUDED IN THIS INSTRUCTION, UNDESIRABLE REACTIONS AND SENSATIONS, AND ALTERING THE CHANGE OF LABORATORY INDICATORS IN THE SYSTEM

Overdose

Cases of overdose are not described.

With an overdose of the drug Flebaven^® seek medical attention immediately.

Interaction with other drugs

Not noted.

IT IS NECESSARY TO INFORM THE MEDICAL DOCTOR ABOUT ALL YOU TAKE MEDICAL PREPARATIONS.

special instructions

• Before you start taking the drug Flebaven^®It is recommended to consult a doctor.
• With exacerbation of hemorrhoids, the use of the drug Flebaven^® does not replace the specific treatment of other anal disorders. The duration of treatment should not exceed the time specified in the section "Dosage and Administration". In the event that the symptoms do not disappear after the recommended course of therapy, a proctologist should be examined, who will select further therapy.
• In the presence of disorders of the venous circulation, the maximum effect of treatment is provided by a combination of therapy with a healthy (balanced) lifestyle: it is advisable to avoid long exposure to the sun, prolonged standing, and it is recommended to reduce overweight. Walking and, in some cases, wearing special stockings, helps to improve blood circulation.

Seek medical attention immediately if your condition worsens or there is no improvement in the treatment process.

Impact on the ability to perform potentially hazardous activities that require special attention and quick reactions (for example, driving, working with moving machinery)

Does not affect.

Pharmacodynamics

The combination of hesperidin + diosmin has venotonic and angioprotective properties. Reduces the elasticity of the veins and venous congestion, in microcirculation - reduces the permeability of capillaries and increases their resistance, improves venous hemodynamics. It affects the following venous plethysmographic parameters: venous capacity, venous distensibility, time of venous emptying. The optimal effect is achieved when taking 2 tablets.

The combination of hesperidin + diosmin increases venous tone by reducing the time of venous emptying. In patients with signs of pronounced impairment of microcirculation, there is an increase in capillary resistance.

The combination of hesperidin + diosmin is effective in the treatment of chronic diseases of the veins of the lower extremities, as well as in the treatment of hemorrhoids.

Pharmacokinetics

Drug Flebaven^® mainly excreted through the intestines. The kidneys, on average, produce about 14% of the accepted dose of the drug.

The half-life is 11 hours.

The drug is subjected to active metabolism, as evidenced by the presence of phenolic acids in the urine.

Release form

Tablets, film coated, 500 mg.

On 16 pills in a blister strip packaging from a film of PVC and aluminum foil.

2, 4 or 6 blister packs together with instructions for use are placed in a pack of cardboard.

Storage conditions

At a temperature not higher than 25 ° С, in the original package.

Keep out of the reach of children.

Shelf life

2 years.

Do not use the drug after the expiration date.

Vacation conditions

Let go without a prescription.