Fluanxol pills 5mg №100

Dosage form

Coated Tablets

Active ingredient

1 pill contains flupentiksol (in the form of a dihydrochloride) 5 mg.

Packing

100 pieces.

Mechanism of action

Antipsychotic agent (neuroleptic), a derivative of thioxanthene with a pronounced antipsychotic, activating and anxiolytic action.
The antipsychotic effect of Fluanxol begins to appear when using the drug in a dose of 3 mg / day, and the intensity of the action increases with increasing dose.
In doses up to 25 mg / day, the drug does not have a sedative effect, but in high doses it can cause a nonspecific sedative effect.
In the entire range of recommended doses, the drug has a pronounced anxiolytic effect.
When taking small doses (up to 3 mg / day), the drug has an antidepressant effect.
Fluanxol reduces the main symptoms of psychosis, incl. hallucinations, paranoid delusions and thinking disorders. It has disinhibiting (anti-anthracistic and activating) properties, and also weakens secondary mood disorders, which helps to activate patients with depressive symptoms, increases their interpersonal skills and facilitates social adaptation.
Fluanxol solution for i / m injection of oil is intended for depot injection, being the deposited form of flupentixol. When using the solution for injection depot in small and medium doses (up to 100 mg 1 time in 2 weeks), the nonspecific sedative effect of the drug does not manifest itself, but can develop with high doses.
Fluanxol in the form of a solution for intramuscular administration (depot injection solution) has a significantly longer duration of action than Fluanxol in the form of tablets, and allows continuous antipsychotic therapy, which is especially important for treating patients who do not follow medical prescriptions. Thus, Fluanxol prevents frequent relapses associated with the voluntary interruption of treatment by patients. Fluanksola injections can be performed at intervals of 2-4 weeks.

Indications and usage

For use of the drug in doses up to 3 mg / dayki
- mild to moderate depression with anxiety, asthenia and lack of initiative;
- chronic neurotic disorders with anxiety, depression and apathy;
- psychosomatic disorders with asthenic reactions;
- acute and situationally conditioned anxiety disorders and states of emotional stress, in which the sedative / hypnotic effect is not required (especially if you suspect that the patient is prone to abuse of tranquilizers).

To use the drug in doses of 3 mg / day or more
- psychotic states with a predominance of hallucinations, paranoid delusions and thinking disorders, also accompanied by apathy, anergy and autism.

Contraindications

- CNS depression;
- acute alcohol intoxication;
- acute intoxication with barbiturates;
- acute intoxication with opioid analgesics;
- coma;
- pathological changes in the blood;
- bone marrow depression;
- pheochromocytoma;
- collapse;
- pregnancy;
- lactation (breastfeeding);
- childhood;
- Hypersensitivity to neuroleptics thioksantenovoy structure.
Patients in a state of excitement or hyperactivity should not be given Fluanxol in insufficiently high doses (up to 3 mg).

Pregnancy and Breastfeeding

Flyuksol not recommended for use during pregnancy and lactation (breastfeeding).

Dosage and administration

For the treatment of depressive and anxiety disorders The initial dose of the drug for oral administration is 1 mg 1 time / day in the morning or 500 mg each 2 times / day. In the absence of a satisfactory therapeutic effect after 1 week, the dose may be increased to 2 mg / day. The daily dose, comprising from 2 mg to 3 mg, should be divided into several doses. In the case of the absence of a therapeutic effect when using Fluanxol at a maximum dose of 3 mg / day for 1 week, the drug should be withdrawn.

In the treatment of psychotic conditions the dose is set individually, depending on the condition of the patient. The initial daily dose is 3-15 mg in 2-3 doses. If necessary, the dose can be increased to 20-30 mg / day. The maximum daily dose is 40 mg.
For maintenance therapy, the drug is used in a dose of 5-20 mg 1 time / day in the morning.

Adverse reactions

Nervous system: weakness, fatigue, psychomotor inhibition, dizziness, mild extrapyramidal hyperkinetics-hypertensive syndrome, akathisia, dystonic reactions, tardive dyskinesia; rarely - neuroleptic malignant syndrome (SNS).
Cardiovascular: orthostatic hypotension, tachycardia.
Hemic and lymphatic: rarely - granulocytopenia.
Special senses: accommodation disturbance.
Gastrointestinal: dry mouth, constipation, transient changes in liver tests, cholestatic jaundice.
On the part of the endocrine system: galactorrhea, gynecomastia, dysmenorrhea, impotence, decreased libido, increased appetite, weight gain, sweating, hot flashes.
Urogenital: urine retention.
Allergic reactions: skin rash, dermatitis, photosensitivity.

Overdosage

Symptoms: drowsiness, hyper- or hypothermia, extrapyramidal disorders, convulsions, hypotension, shock, coma are possible.
Treatment: conduct symptomatic and supportive therapy. In the case of taking the drug inside it is necessary to wash the stomach as soon as possible, it is recommended to take a sorbent. Measures should be taken to support the activity of the respiratory and cardiovascular systems. Do not use epinephrine (epinephrine), because this can lead to a subsequent decrease in blood pressure. Spasms can be stopped by diazepam, and extrapyramidal symptoms - biperidenom.

Store at a temperature not exceeding 30 ° C.