Fluoxetine capsules 20mg №20

Active ingredient and dosage form

Fluoxetine capsules: 1 capsule contains Fluoxetine 10 or 20 mg;

Mechanism of action

Fluoxetine - antidepressant, selective serotonin reuptake inhibitor. It improves mood, reduces tension, anxiety and fear, eliminates dysphoria. Does not cause orthostatic hypotension, sedation, non-cardiotoxic. When taken in moderate therapeutic doses, it practically does not affect the function of the cardiovascular and other systems.
Persistent clinical effect develops after 2 weeks of regular use of the drug.

Depression (regardless of the degree of depressive disorder - mild, moderate, severe), bulimia, anorexia, alcoholism, obsessive states.

Contraindications

- Atony of the bladder;
- pronounced impaired renal function;
- simultaneous administration of MAO inhibitors;
- glaucoma;
- prostate adenoma;
- convulsive syndrome of various genesis;
- epilepsy;
- pregnancy;
- lactation (breastfeeding);
- Hypersensitivity to the drug.

Dosage and administration

With depression of various origins The initial dose of Fluoxetine 20 mg 1 time / day in the morning. If necessary, the dose of the drug may be increased.
The maximum daily dose is 80 mg in 2-3 doses.
For bulimia and for elderly patients the drug is prescribed 20 mg 3 times / day,with obsessive-compulsive disorder - 20-60 mg / day. Maintenance therapy - 20 mg / day. The course of treatment is 3-4 weeks.

Adverse reactions

From the side of the central nervous system: headache, nervousness, sleep disturbance, increased anxiety, fatigue.
From the digestive tract: nausea, diarrhea, dry mouth, vomiting, loss of appetite.
Allergic reactions in the form of skin rash, angioedema, urticaria, itching.
Other: decrease in libido, feeling of heat, hyponatremia.

Cautions

When treating patients with a body mass deficiency, anorexigenic effects should be taken into account (progressive loss of body weight is possible).
In diabetics, the prescription of fluoxetine increases the risk of hypoglycemia and hyperglycemia when it is canceled. In this regard, the dose of insulin and / or any otherhypoglycemic drugs used internally must be adjusted. Before the onset of a significant improvement in treatment, patients should be under the supervision of a physician.
During treatment, one should refrain from taking ethanol and practicing potentially hazardous activities that require increased attention and speed of mental and motor responses.
The interval between the end of therapy with MAO inhibitors and the start of treatment with fluoxetine should be at least 14 days; between the end of treatment with fluoxetine and the start of therapy with MAO inhibitors - at least 5 weeks.
With liver disease and in old age, treatment should begin with a half dose.

Drug Interactions

Enhances the effects of alprazolam, diazepam, ethanol and hypoglycemic drugs.
Increases in plasma the concentration of phenytoin, tricyclic antidepressants, maprotiline, trazodone 2 times (it is necessary to reduce the dose of tricyclic antidepressants by 50% with simultaneous use). On the background of electroconvulsive therapy, the development of long-term epileptic seizures is possible.
Tryptophan increases the serotonergic properties of fluoxetine (increased agitation, motor anxiety, disorders of the gastrointestinal tract).
MAO inhibitors increase the risk of serotonin syndrome (hyperthermia, chills, increased sweating, myoclonus, hyperreflexia, tremor, diarrhea, impaired motor coordination, autonomic lability, agitation, delirium and coma).
Drugs that have a depressant effect on the central nervous system increase the risk of side effects and enhance the inhibitory effect on the central nervous system.
With simultaneous use with drugs with a high degree of protein binding, especially with anticoagulants and digitoxin, it is possible to increase the concentration in plasma of free (unbound) drugs and increase the risk of adverse effects.

The drug should be stored in a dry, dark place.

- 2 years.