Acyclovir pills 400mg №35

Group 

Antiherpetic drugs

Composition 

Active ingredient: Acyclovir.

International non-proprietary name

Acyclovir

Synonyms 

Atsigerpine, Atsik-ophtal, Acyclovir Belupo, Atsiklovir Geksal, Atsiklovir Sandoz, Atsiklovir forte, Atsiklovir-Akos, Atsiklovir-Akri, Atsiklostad, Vero-Atsiklovir, Vivoks, Viroleks, Gerviraks, Gerpevir, Tehers Cevirin, Sediko Cycloviral

pharmachologic effect

Antiviral. It has a highly selective effect on herpes simplex viruses type 1 and 2, shingles, Epstein-Barr and cytomegalovirus. Easily passes through the corneal epithelium (eye ointment) and creates a therapeutic concentration in the eye fluid. When used topically as a cream, it is not absorbed into the systemic circulation. It penetrates the BBB and placental barrier, is excreted in breast milk. When herpes prevents the formation of new elements of the rash, reduces the likelihood of skin dissemination and visceral complications, accelerates the formation of crusts, reduces pain in the acute phase of herpes zoster. It has an immunostimulating effect.

Indications for use

Primary and recurrent herpetic lesions of the skin and mucous membranes (including genital herpes), herpetic lesions in patients with immunodeficiency (treatment and prevention), herpes zoster, chickenpox,simple herpetic keratitis.

Contraindications 

Hypersensitivity, breastfeeding.

Side effect

Headache, fatigue, neurological disorders, shortness of breath, nausea, vomiting, diarrhea, intestinal colic, fever, edema, lymphadenopathy, increased bilirubin, urea, creatinine, a transient increase in liver transaminase, allergic reactions in the form of skin rash, itching. When a / in the introduction - arousal, impaired consciousness, lethargy, tremor, convulsions, hallucinations, psychosis, coma; reactions at the site of intravenous injection — local inflammation, phlebitis. When applied externally - erythema, peeling, burning sensation, burn.

Interaction

Probenecid slows down the excretion (blocks tubular secretion).

Dosing and Administration

Inside, adults and children over 2 years old - 0.2 g 5 times a day (excluding the night), for prevention - 0.2 g 4 times a day; with shingles - 0.8 g 4 times a day; Children under 2 years old - half the dose for adults. The course of treatment is usually 5 days, with herpes zoster - 3 more days after the disappearance of the signs of the disease. Preventive treatment for organ transplants is carried out for 6 weeks.

Overdose 

Symptoms: headache, neurological disorders, shortness of breath, nausea, vomiting, diarrhea, renal failure, lethargy, convulsions, coma. Treatment: maintenance of vital functions, hemodialysis.

special instructions

Restrictions on the use: Pregnancy.To prevent crystallization in the tubular apparatus, the intake of large amounts of fluid is recommended. Caution should be exercised in patients with psychoneurotic disorders, impaired renal function and liver, electrolyte disturbances, severe hypoxia. Applying the cream is recommended to wear rubber gloves to prevent infection of other skin areas. For more information, see the instructions for use.

Storage conditions

In a dry place, at a temperature not higher than 25 ° C.