Indomethacin candles 50mg №6

Active ingredient and dosage form

Indomethacin coated tablets:
1 pill contains Indomethacin 25 mg;
30 pcs in pack.

Indomethacin ointment 10% for external use:
1 g contains indomethacin 100 mg;
in tubes of 40g.

rectal suppositories:
1 suppository contains indomethacin 50 or 100 mg;
6 pieces packaged.

Nonsteroidal anti-inflammatory agent

Mechanism of action

Indomethacin has a local anesthetic, anti-inflammatory and anti-edema effect.
When applied externally, it eliminates pain, reduces swelling and erythema, helps reduce morning stiffness and swelling of joints, and increases the range of motion.

For system use: articular syndrome (rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout), back pain, neuralgia, myalgia, traumatic inflammation of soft tissues and joints, rheumatism, diffuse connective tissue diseases, dysmenorrhea. As an adjunct in infectious-inflammatory diseases of the upper respiratory tract, adnexitis, prostatitis, cystitis.
For local use: prevention of the inflammatory process in surgical interventions for cataracts and in the anterior segment of the eye, inhibition of miosis during surgery.
For external use: articular syndrome (rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout), back pain, neuralgia, myalgia, traumatic inflammation of soft tissues and joints.

Contraindications

- Individual hypersensitivity to indomethacin, Aspirin or another NSAID (in the history of bronchospasm, urticaria or rhinitis, caused by the administration of Acetylsalicylic acid or other NSAIDs);
- peptic ulcer of the stomach and / or intestines in the acute phase;
- pregnancy and lactation;
- children's age (up to 14 years).
- violations of blood formation;
- severe impaired function of the liver and / or kidneys;
- severe forms of chronic heart failure, arterial hypertension, pancreatitis;
- for rectal use: proctitis, recent rectal bleeding.

Dosage and administration

Ointment rub a thin layer into the skin of painful areas of the body 2-3 times a day. The total amount per day should not exceed 15 cm ointment for adults and 7.5 cm for children over 14 years old.

For local use in ophthalmology, the dose frequency and duration of use are determined individually.

Pills: Inside, during or after a meal, drinking milk, adults - in the initial dose of 25 mg 2-3 times a day. With insufficient severity of the clinical effect, the dose is increased to 50 mg 3 times a day. The maximum daily dose is 200 mg. When effect is achieved, treatment is continued for 4 weeks in the same or reduced dose. With prolonged use, the maximum daily dose is 75 mg.

Suppositories: rectally (injected into the rectum). Before using the suppository, it is recommended to empty the intestines.
Suppositories 50 mg for adults 1-3 times a day; children (over 14 years old) Once a day;
Suppositories 100 mg - 1 time per day;
During a gout attack, up to 200 mg per day.
It is recommended to apply for the night.

Gastrointestinal: nausea, anorexia, vomiting, pain and discomfort in the abdomen, constipation or diarrhea, erosive and ulcerative lesions, bleeding and perforation of the gastrointestinal tract; rarely - intestinal strictures, stomatitis, gastritis, flatulence, bleeding from the sigmoid colon or diverticulum, jaundice, hepatitis.
Nervous system: dizziness, headache, depression, feeling tired; rarely - anxiety, fainting, drowsiness, convulsions, peripheral neuropathy, muscle weakness, involuntary muscle movements, sleep disorders, mental disorders (depersonalization, psychotic episodes), paresthesia, dysarthria, parkinsonism.
Cardiovascular: edema, increased blood pressure, tachycardia, chest pain, arrhythmia, palpitation, hypotension, congestive heart failure, hematuria.
Allergic reactions: rarely - itching, urticaria, vasculitis, erythema nodosum, skin rash, exfoliative dermatitis, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, hair loss, acute respiratory distress, a sharp drop in blood pressure, anaphylaxis, angioedema, dyspnea, bronchial asthma, pulmonary edema.
Hemic and lymphatic: rarely - leukopenia, petechiae or ecchymosis, purpura, aplastic and hemolytic anemia, thrombocytopenia, DIC syndrome.
Special senses: rarely - a violation of the clarity of visual perception, diplopia, orbital and periorbital pain, tinnitus, hearing impairment, deafness.
Urogenital: rarely - proteinuria, nephrotic syndrome, interstitial nephritis, renal dysfunction, renal failure.
Metabolism: rarely - hyperglycemia, glycosuria, hyperkalemia.
Other: rarely - vaginal bleeding, hot flashes, increased sweating, nosebleeds, breast enlargement and tension, gynecomastia.
Local reactions: in some cases of intramuscular administration, in some cases - the formation of infiltration, abscess; with rectal use, irritation of the rectal mucosa, tenesmus, exacerbation of chronic colitis are possible.
For external use: itching, redness, rash at the site of application.