Isoprinosine pills 500mg №30

Release form

Pills

Composition

1 pill contains inosine pranobex 500 mg

Packaging

30 pieces

pharmachologic effect

Isoprinosine is an immunostimulating drug with an antiviral effect, a synthetic complex derivative of purine, which has immunostimulating activity and a nonspecific antiviral effect.

Restores lymphocyte function under immunodepression conditions, increases blastogenesis in a population of monocytic cells, stimulates the expression of membrane receptors on the surface of T-helper cells, prevents a decrease in the activity of lymphocytic cells under the influence of glucocorticosteroids, and normalizes the inclusion of thymidine in them. Isoprinosine has a stimulating effect on the activity of cytotoxic T-lymphocytes and natural killer cells, the function of T-suppressors and T-helper cells, increases the production of IgG, Interferon gamma, interleukins (IL) -1 and IL-2, reduces the formation of proinflammatory cytokines - IL-4 and IL-10, potentiates the chemotaxis of neutrophils, monocytes and macrophages.

The drug exhibits antiviral activity in vivo against Herpes simplex viruses, cytomegalovirus and measles virus, human type III T-cell lymphoma virus, polioviruses, influenza A and B, the ECHO-virus (human enterocytopathogenic virus), encephalomyocarditis and equine encephalitis. The mechanism of antiviral action of izoprinozin is associated with inhibition of viral RNA and the enzyme dihydropteroate synthetase, which is involved in the replication of certain viruses, enhances viral-suppressed lymphocyte mRNA synthesis, which is accompanied by suppression of viral RNA biosynthesis and translation of viral proteins, increases the production of lymphocytes with antiviral properties of interferon alfa and the alpha viral proteins of interferon alfa and infected by the viral proteins and alpha antibodies.

With a combined appointment enhances the action of interferon-alpha, antiviral drugs Acyclovir and zidovudine.

Indications

- Treatment of flu and other acute respiratory viral infections
- infections caused by the Herpes simplex virus types 1, 2, 3 and 4: genital and labial herpes, herpetic keratitis, shingles, chicken pox;
- infectious mononucleosis caused by Epstein-Barr virus;
- cytomegalovirus infection;
- Measles severe course;
- human papillomavirus infection: laryngeal / vocal cord papillomas (fibrous type), genital papillomavirus infection in men and women, warts;
- molluscum contagiosum.

Contraindications

Hypersensitivity to the drug.
Gout, urolithiasis, chronic renal failure, arrhythmias, pregnancy, breastfeeding, children under 3 years old (body weight up to 15-20 kg).

Dosage and administration

Isoprinosine pills are taken after meals with a small amount of water.

The recommended daily intake for adults and children aged 3 years and older (weighing 15-20 kg) is 50 mg / kg of body weight in 3-4 doses, which is on average 6-8 pills per day for adults, for children - 1/2 pill per 5 kg of body weight per day.

In severe forms of infectious diseases The dose can be increased individually to 100 mg / kg of body weight per day, divided into 4-6 doses. The maximum daily dose for adults 3-4 g / day, for children aged 3 years and older - 50 mg / kg / day

Duration of treatment:
Acute diseases in adults and children aged 3 years and older usually range from 5 to 14 days. Treatment should be continued until the clinical symptoms disappear and for 2 more days in the absence of symptoms. If necessary, the duration of treatment can be increased individually under the supervision of a physician.

In chronic recurrent diseases in adults and children aged 3 years and older, treatment should be continued in several courses of 5-10 days with a break in reception in 8 days.

For maintenance therapy, the dose can be reduced to 500-1000 mg per day (1-2 tablets) for 30 days.

For herpes infection adults and children aged 3 years and older should prescribe the drug for 5-10 days until the symptoms of the disease disappear, in the asymptomatic period, 1 pill 2 for 30 days to reduce the number of relapses.

With human papillomavirus infection adults take 2 pills 3 per day, children aged 3 years and older - 1/2 pill per 5 kg / body weight per day in 3-4 doses for 14-28 days as monotherapy.

With recurrent genital warts adults are prescribed 2 pills 3, children aged 3 years and older - 1/2 pills per 5 kg / body weight per day in 3-4 doses, either as monotherapy or in combination with surgical treatment for 14-28 days, then with a threefold repetition of the specified course at intervals of 1 month.

With cervical dysplasia associated with human papillomavirus, the drug is prescribed 2 pills 3 for 10 days, then spend 2-3 similar courses with an interval of 10-14 days.

Side effects

From the digestive tract: often - nausea, vomiting, epigastric pain, sometimes diarrhea, constipation.
Liver and biliary tract:often - a temporary increase in the activity of transaminases and alkaline phosphatase in the blood plasma, an increase in the urea content in the blood plasma.
From the skin: often - itching.
Nervous system: often - headache, dizziness, weakness; sometimes drowsiness, insomnia.
Urogenital: sometimes polyuria.
Musculoskeletal system:often - pain in the joints, aggravation of gout.

special instructions

It is necessary to periodically determine the content of uric acid in the serum and urine, with long-term use - monitoring of the functions of the liver, kidneys and peripheral blood cell composition.

Drug interaction

Immunosuppressants may decrease the effectiveness of isoprinosine.

Xanthine oxidase inhibitors and uricosuric agents (including diuretics) may contribute to the risk of an increase in the level of uric acid in the blood serum of patients.

Storage conditions

Store in a dry, dark place at a temperature not exceeding 25 ° C.