Buy Kalimin 60 n tablets 60mg №100
  • Buy Kalimin 60 n tablets 60mg №100

Kalymin 60 n pills 60mg №100

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Dosage form

Pills

Composition

1 pill contains: pyridostigmine bromide 60 mg.

Excipients: microcrystalline cellulose, corn starch, polyvidone K25, precipitated silicon dioxide, highly dispersed silicon dioxide, Magnesium stearate, glutamic acid hydrochloride, water.

Packaging

In a bottle of dark glass 100 tablets. In the package 1 bottle.

Mechanism of action

Kalymin 60 N - acetylcholinesterase inhibitor.

It has an indirect cholinomimetic effect due to reversible inhibition of acetylcholinesterase and enhancing the action of endogenous acetylcholine. It improves neuromuscular transmission, increases the motility of the gastrointestinal tract, increases the tone of the bladder, bronchi, secretion of exocrine glands, causes bradycardia, weak miosis, accommodation spasm.

Indications and usage

- Myasthenia.
- Myasthenic syndrome.
- Atony of the muscles of the digestive tract.
- Atony of the bladder.

Contraindications

- Hypersensitivity to the drug.
- Obstructive intestinal obstruction.
- Spasm of the biliary and urinary tract.
- Spastic states of the digestive tract.
- Myotonia.
- Shock in the postoperative period.
- Thyrotoxicosis.
- Parkinsonism.
- Bronchial asthma.
- Chronic obstructive bronchitis.
- Simultaneous use of depolarizing muscle relaxants (suxametonium, decametonium).
- Irit.
- Lactation (breastfeeding).

Given the high content of the active substance, Kalymin 60 N is not used to treat atony of the muscles of the gastrointestinal tract and bladder in children under 16 years of age.

Precautions should be prescribed the drug in the following cases:

- Arterial hypotension.
- Heart and kidney failure.
- Acute myocardial infarction.
- Peptic ulcer of the stomach and duodenum.
- Bradycardia.
- Diabetes.
- Operations on the digestive tract.
- Liver disease.

Pregnancy and Breastfeeding

Precautions should be prescribed the drug during pregnancy.

Kalymin 60 N is contraindicated during lactation (breastfeeding).

Dosage and administration

With the initial symptoms of myasthenia, the drug is prescribed in a daily dose of 30-120 mg in 1 or 2 doses, with the progression of the disease - 120-720 mg in 2-4 doses.The maximum daily dose is 720 mg.

When atony of the muscles of the gastrointestinal tract and bladder Kalymin 60 N is prescribed in a dose of 60 mg every 4 hours.

Adverse reactions

Gastrointestinal: nausea, vomiting, diarrhea, abdominal pain, increased peristalsis.

Cardiovascular: decrease in blood pressure, bradycardia.

Dermatologic: skin rash (due to the content in the preparation of bromine).

Other: hypersecretion of bronchial glands, salivation, lacrimation, sweating, frequent urination, miosis, convulsions, muscle fasciculations, muscle weakness.

Special notes

The patient should be informed that if he has forgotten to take the next dose of the drug in a timely manner, this dose should not be taken in addition to the prescribed dosing regimen.

In the process of treatment patients are prohibited from drinking alcohol.

Precautions should be prescribed the drug for renal failure. Patients with kidney disease drug is prescribed in lower doses. The required dose is selected individually.

Influence on ability to drive motor transport and control mechanisms: Kalymin 60 N can cause a slowdown in the speed of psychomotor reactions. You should avoid driving a car and doing other activities that require high concentration of attention, speed of psychomotor reactions.

Drug interactions

Atropine reduces the side effects of pyridostigmine such as bradycardia and hypersecretion.

Pyridostigmine enhances the action of depolarizing muscle relaxants, morphine derivatives and barbiturates.

M-holinoblockers, ganglioblockers, quinidine, procainamide, local anesthetics, tricyclic antidepressants, anti-epileptic and anti-parkinsonic drugs reduce the severity of the action of pyridostigmine.

Overdosage

Symptoms: increased secretion of lacrimal, salivary and sweat glands, skin flushing, severe weakness, blurred vision, miosis, dizziness, nausea, vomiting, involuntary defecation and urination, intestinal colic, bronchospasm, pulmonary edema, severe or growing muscle weakness, respiratory muscle paralysis, the disease HELL, collapse, bradycardia, paradoxical tachycardia, cardiac arrest.
Treatment: the abolition of the drug, in / in the introduction of (slowly) atropine sulfate in a dose of 1-2 mg. If necessary and depending on the heart rate, repeated administration of atropine sulfate is possible in the same dose in 2-4 hours. Symptomatic therapy is carried out.

Storage conditions

The drug should be stored at a temperature not higher than 30 ° C.

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