Climen pills coated №21

Active ingredient and dosage form

Klymen dragee white and pink flowers:
1 dragee of white color (11 pieces in unitary enterprise.) Contains estradiol valerate 2 mg,
1 pink bean (10 pcs. In a pack.) Contains estradiol valerate 2 mg, cyproterone acetate 1 mg;

21 pieces packaged.

Mechanism of action

Klymen - a combined preparation containing estrogen - estradiol valerate and an antiandrogen - cyproterone acetate, which has gestagenic properties. It is a means of hormone replacement therapy that replenishes the lack of sex hormones in a woman’s body. Hormone replacement therapy reduces or eliminates the symptoms of menopausal disorders, with long-term use has a preventive effect on the development of osteoporosis and cardiovascular diseases.
Klymene well controls the menstrual cycle and therefore may be useful for women with irregular menstruation or in cases where menstruation is absent and pregnancy or organic causes of the absence of menstruation are excluded. Climen can cause regular monthly bleeding, even if the woman has already run out of natural menstruation.
Estradiol valerate eliminates or reduces the symptoms that appear due to a decrease in perimenopausal estrogen levels, such as hot flashes, sweating, sleep disturbances, irritability, depressions, memory disorders, vascular crises, atrophic degenerative changes of the skin and mucous membranes (increased fragility of the nails, thinning of the skin and the formation of wrinkles, dryness of the mucous membranes of the urogenital tract), involuntary urination, osteoporosis and increased fragility of the bones, changes in lipid metabolism, Significant increase in LDL levels, which cause atherosclerotic changes in the vessels.
Cyproterone acetate, due to the presence of gestagenic properties, contributes to secretory changes in the proliferating epithelium of the uterus and other target organs, which stops the further development of proliferative processes leading to the development of hyperplasia, in particular, the growth of hormone-dependent progesterone-deficient tumors.Cyproterone acetate, due to the presence of antiandrogenic activity, reduces the effects of androgenization in patients. Virtually no effect on lipid metabolism, which contributes to a more complete implementation of the prophylactic effect of estradiol valerate in relation to cardiovascular diseases in menopause.

Indications and usage

Hormone replacement therapy for menopausal disorders, manifested by psycho-emotional, vegetative-vascular, urogenital disorders, atrophic processes on the skin, involution of the bladder and genital organs, androgenization phenomena;
Postmenopausal osteoporosis prevention;
Estrogen deficiency after oophorectomy for non-oncological diseases;
Treatment of menstrual disorders (including primary and secondary amenorrhea).

Dosage and administration

Climen is prescribed from the 5th to the 25th day of the menstrual cycle daily. Drops are taken at the same time, without chewing, with a small amount of liquid.
After receiving Klymene from 1 calendar package, a break is taken for 7 days, during which approximately 2-4 days after the last dragee is taken, menstrual-like bleeding begins.
After a 7-day break, they start taking Climen from the next calendar pack. In the absence of a 7-day break of bleeding, taking the drug should be continued only after the exclusion of pregnancy.
Patients in menopause (in the absence of menstruation), as well as amenorrhea or bleeding after oophorectomy, Climen is prescribed independently of the phases of the cycle 1 pill / day for 21 days with a 7-day break. In case of skipping the drug intake at the scheduled time, Klimen must be taken within the next 12 hours.

Adverse reactions

On the part of the endocrine system: rarely - a feeling of tension, soreness and an increase in the mammary glands, a change in body weight.
Gastrointestinal: rarely - discomfort in the epigastric region, nausea, vomiting, flatulence, increased appetite.
From the side of the central nervous system: in some cases - headache, migraine, dizziness, fatigue, decrease in mood, visual impairment.
From the reproductive system: in the first months of administration, the occurrence of spotting intermenstrual bleeding, changes in libido, dysmenorrhea, a condition resembling premenstrual syndrome, changes in vaginal secretion.
Other: skin rash, impaired tolerance of contact lenses, allergic reactions, palpitations, swelling, muscle cramps.

Contraindications

Pregnancy; lactation; breast cancer and suspicion of it; hormone-dependent neoplasms or suspicion of them; benign or malignant tumors of the liver (including in history); severe liver disease; deep vein thrombosis of the lower extremities (including in history); severe hypertriglyceridemia; hypersensitivity to the drug.

Special notes

Climen is not a contraceptive.
Before starting to use Klymene, it is recommended to undergo a general medical and gynecological examination (including examination of the mammary glands) in order to exclude the above contraindications. With prolonged use of Klymene, you should undergo follow-up medical examinations every 6 months.
Before starting treatment for secondary amenorrhea, it is necessary to make sure that the patient does not have a prolactin-producing pituitary tumor.
In the event of repeated bleeding in the initial 3-month period of treatment with Climen, control by a physician is necessary without discontinuing the drug.
The drug should be discontinued when the first appearance of unusually strong, migraine-like or frequent headaches, with unexpected vision or hearing impairment, at the first signs of thrombosis (unusual pain in the limbs, swelling, pain and pressure in the chest), with the appearance of jaundice, intensification and increase of epileptic seizures, with a significant increase in blood pressure, pregnancy.
When prescribing HRT, the state of health of patients with epilepsy, benign breast tumors, asthma, migraine, porphyria, otosclerosis, systemic lupus erythematosus, and small chorea should be especially carefully monitored.
To prevent pregnancy in premenopausal patients, it is recommended, if necessary, to use non-hormonal methods of contraception (with the exception of the Knaus-Oguino calendar method and the temperature method).
With prolonged drug treatment increases the likelihood of cessation of menstruation.
After suffering viral hepatitis, Klymene can be taken only after 6 months.
Use of the drug should be discontinued 6 weeks before the scheduled surgical operations, as well as in cases of appointment of long bed rest (for example, after accidents).
When using Climen, a change in glucose tolerance is possible, therefore, patients with diabetes mellitus may require correction of doses of hypoglycemic drugs.

Store at room temperature.
Shelf life - 5 years.