Lindynette 20 pills №21

Packaging

21 pieces

Mechanism of action

Lindynette is a monophasic gestagen-estrogenic contraceptive drug. Inhibits the secretion of pituitary gonadotropic hormones, inhibits the maturation of follicles and interferes with the process of ovulation. It increases the viscosity of cervical mucus, making it difficult for sperm to enter the uterus.
Lindinet, in addition to preventing pregnancy, has a positive effect on the menstrual cycle (when it is disturbed): the monthly cycle becomes regular, the volume of blood loss during menstruation and the incidence of iron deficiency anemia decreases, the frequency of dysmenorrhea decreases, the incidence of functional ovarian cysts decreases, the frequency of ectopic pregnancy decreases.
The use of the drug reduces the incidence of fibroadenomas and fibrous cysts in the mammary glands, inflammatory diseases of the pelvic organs and endometrial cancer. Improves skin condition with acne.

Indications and usage

Contraception.

Contraindications

• diseases accompanied by severe liver dysfunction;
• liver tumors (including in history);
• thrombosis and thromboembolism (including in history);
• myocardial infarction (including in history);
• heart failure;
• cerebrovascular disorders (including history);
• conditions preceding thrombosis (including transient ischemic attacks, angina);
• coagulopathy;
• sickle cell anemia;
• estrogen-dependent tumors, incl. breast tumors (including history);
• diabetes mellitus complicated by microangiopathies;
• uterine bleeding of unknown etiology (until the cause is clarified);
• idiopathic jaundice and itching during pregnancy;
• history of herpes genitalia;
• otosclerosis with deterioration during a previous pregnancy;
• pregnancy;
• hypersensitivity to Lindynette components.

Pregnancy and Breastfeeding

The drug is contraindicated for use in pregnancy. If necessary, the appointment of the drug during lactation should decide on the termination of breastfeeding. The active ingredients of the drug in small quantities are excreted in breast milk, affecting the quantity and quality of milk.

Dosage and administration

The drug should be taken from the 1st to the 5th day of menstruation at 1 pill / day (if possible at the same time of day) for 21 days, followed by a 7-day break. During a 7-day break, menstrual bleeding appears. After a 7-day break, regardless of whether the bleeding has ended or is just beginning, continue taking the drug from the next package. Thus: 3 weeks - taking pills, 1 week - a break. Taking the drug from each new package starts on the same day of the week.
First reception drug Lindynette 20 must begin with 1-5-th day of the menstrual cycle.
After abortion in the first trimester of pregnancy You can start taking the drug Lindynette 20 immediately after surgery. In this case, there is no need to use additional methods of contraception.

After childbirth The drug can be started in 21-28 days, if the woman is not breastfeeding. Nursing women are recommended to start taking pills 6 months after delivery. In these cases, in the first 7 days it is necessary to apply additional methods of contraception. If after childbirth or abortion there was already sexual contact, then before starting the drug you should exclude pregnancy or postpone the beginning of the reception until the first menstruation.
When skipping taking the missed pill should be taken as soon as possible. If the interval in taking pills was less than 36 hours, then the effectiveness of the drug will not decrease, and in this case there is no need to use an additional method of contraception. The remaining pills should be taken at the usual time. If the interval is more than 36 hours, the effectiveness of the drug may decrease. In this case, the woman should take the missed pill, and the next pill she should take as normal and in the next 7 days it is necessary to use additional barrier methods of contraception.If less than 7 tabs are left in the package, you should start taking the drug from the next package without interruption. In this case, menstrual-like bleeding does not occur until the completion of taking the drug from the second package, but there may be spotting or breakthrough bleeding.

If menstrual bleeding does not occur after the completion of the drug from the second package, then continue to take the drug before continuing the drug.
If vomiting and / or diarrhea begins within 3-4 hours after taking the drug, a decrease in the contraceptive effect is possible. If the symptoms stopped within 12 hours, then you need to take another 1 pill extra. After that, you should continue taking the pills in the usual way. If the symptoms of diarrhea continue for more than 12 hours, it is necessary to use additional methods of contraception in the next 7 days.
To delay menstruation taking the drug should be continued from the new package without a 7-day break. Menstruation can be delayed as long as necessary until the end of the last pill in the second pack. With delayed menstruation, breakthrough or spot bleeding may occur. Regular intake of the drug Lindynette 20 can be restored after the usual 7-day break.
Tablets should be taken orally, without chewing, drinking plenty of water, regardless of the meal.

Adverse Effects

Cardiovascular: rarely - thromboembolism, thrombosis (including retinal vessels), increased blood pressure.
Gastrointestinal: sometimes nausea, vomiting.
From the reproductive system: sometimes - intermenstrual bleeding, changes in vaginal secretion.
On the part of the endocrine system: sometimes - a feeling of tension in the mammary glands, changes in body weight, changes in libido.
From the side of the central nervous system: emotional lability, depression, dizziness, headaches, migraine, weakness, fatigue.
Other: abdominal pain, chloasma, discomfort when wearing contact lenses, fluid and sodium retention in the body, allergic reactions, impaired glucose tolerance.

Special notes

with extra care the drug should be prescribed if there are cases of breast cancer in the family history, with chorea of ​​pregnant women (a previous appointment can worsen the course of chorea for pregnant women), diabetes, epilepsy, gall bladder diseases, especially cholelithiasis (includinghistory), liver failure, cholestatic jaundice (including in pregnant women in history), arterial hypertension, prolonged immobilization, major surgical procedures, depression (including history), migraine.
Smoking during the period of use of hormonal contraceptives increases the risk of cardiovascular complications. This risk increases with age (over 35 years). Therefore, women taking Lindynette, it is recommended to stop smoking or reduce the number of cigarettes smoked.
Women with a history of hypertension or kidney disease, during the period of taking Lindynette 20 should carefully monitor blood pressure and, if there is a significant increase in it, the drug should be stopped. In most patients with discontinuation of the drug, blood pressure returns to normal.
The risk of venous thromboembolic diseases (VTZ) in women taking oral hormonal contraceptives is slightly higher than that of non-taking. However, this risk is less significant than the risk of VTZ pregnant women. Out of 100,000 pregnant women, approximately 60 have VTZ, while the incidence of VTZ among women who take gestodene in combination is about 30-40 cases out of 100,000 women per year.
The risk of the onset of arterial or venous thromboembolic diseases is increased by the following factors: age over 35, smoking, a positive family history of high-temperature control, obesity (body mass index higher than 30 kg / m²), impaired fat metabolism, arterial hypertension, valvular disease, atrial fibrillation, prolonged immobilization, severe surgery, surgery on the legs, severe injury.
Due to the fact that the risk of thromboembolic diseases increases in the postoperative period, it is necessary to stop taking the drug 4 weeks before the planned operation and resume taking 1 week after the patient is activated.
With the onset or worsening of the course of migraine or with the appearance of a constant or unusually severe headache, the drug should be stopped.
Taking the drug Lindynette should be immediately stopped when a generalized itching occurs, with the development of an epileptic seizure.

Lindinet's contraceptive activity is reduced when taken with ampicillin, Tetracycline , rifampicin, barbiturates, Carbamazepine , phenylbutazone, phenytoin, Griseofulvin , topiramate , felbamate, oxcarbazepine. During the reception of Lindynette 20 with the above drugs, as well as within 7 days after completion of the course of their reception, you must use additional non-hormonal (condom, spermicidal gels) methods of contraception. When using rifampicin, additional contraceptive methods should be used within 4 weeks after completing the course of its administration.
With simultaneous use with Lindynette, any drug that improves gastrointestinal motility decreases the absorption of active substances and their level in blood plasma.
Drugs that inhibit the activity of liver enzymes (including itraconazole, fluconazole), increase the concentration of ethinyl estradiol in the blood plasma.
With the simultaneous use of Lindynette with preparations of Hypericum (including infusion), the concentration of active substances in the blood decreases, which can lead to breakthrough bleeding and pregnancy. The reason for this is the inducing effect of Hypericum on liver enzymes, which continues for another 2 weeks after completing the course of Hypericum.
Ethinyl estradiol sulfation occurs in the intestinal wall. Preparations that also undergo sulfation in the intestinal wall (including ascorbic acid) competitively inhibit the sulfation of ethinyl estradiol and thereby increase the bioavailability of ethinyl estradiol.
Ethinyl estradiol by inhibiting liver enzymes or accelerating conjugation (primarily glucose) may affect the metabolism of other drugs (including cyclosporine, theophylline); the concentration of these drugs in the blood plasma may increase or decrease.
Ritonavir reduces ethinyl estradiol AUC by 41%. In this regard, during the use of ritonavir, hormonal contraceptives with a higher content of ethinyl estradiol should be used or additional non-hormonal methods of contraception should be used.

Symptoms: nausea, vomiting, vaginal bleeding.
Treatment: prescribed symptomatic therapy, there is no specific antidote.

Store at a temperature not exceeding 30 ° C, out of the reach of children.