Norbactin pills 400mg №20

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to norfloxacin.

For oral administration: diseases of the urinary tract, prostate, gastrointestinal tract, gonorrhea, prevention of recurrence of urinary tract infections, bacterial infections in patients with granulocytopenia, "travelers' diarrhea."

For topical use: conjunctivitis, keratitis, keratoconjunctivitis, corneal ulcers, blepharitis, blepharoconjunctivitis, acute inflammation of the meibomian glands and dacryocystitis, prevention of eye infections after removal of a foreign body from the cornea or conjunctiva, after using chemical substances of the eye infections after removal of the cornea or conjunctiva after the chemical, after using chemical substances of the eye infections after removing the body from the cornea or conjunctiva, after using chemical substances, preventing eye infections after the removal of the cornea or conjunctiva after the damage, after using chemical substances, preventing eye infections after the removal of the body from the cornea or conjunctiva, after using chemical substances, preventing eye infections after the removal of the body from the cornea or conjunctiva, after using chemical substances, preventing eye infections after the removal of the body from the cornea or conjunctiva, after using chemical substances, preventing eye infections after the removal of the body from the cornea or conjunctiva, after using chemical substances, to prevent eye infections after removing the body from the cornea or conjunctiva; otitis externa, acute otitis media, chronic otitis media, prevention of infectious complications during surgical interventions on the organ of hearing.

Dosage and administration

Individual. A single dose for oral administration is 400-800 mg, the multiplicity of use - 1-2 times / day. The duration of treatment is determined individually.

In ophthalmology and ENT-practice used locally.

Side effect

Gastrointestinal: nausea, heartburn, anorexia, diarrhea, abdominal pain.

From the side of the central nervous system: headache, dizziness, fatigue, sleep disorders, irritability, anxiety.

Allergic reactions: skin rash, itching, angioedema.

Co side of the urinary system: interstitial nephritis.

Contraindications

Pregnancy, lactation (breastfeeding), childhood and adolescence (up to 15 years), deficiency of glucose-6-phosphate dehydrogenase, hypersensitivity to norfloxacin and other quinolone preparations.

Use during pregnancy and lactation

Norfloxacin is contraindicated during pregnancy and lactation (breastfeeding), because in experimental studies it was found that it causes arthropathy.

Application for violations of the liver

It should be used with caution in patients with severely impaired liver function.

Application for violations of kidney function

It should be used with caution in patients with severe renal impairment.

Use in children

Contraindicated in children and adolescents (up to 15 years).

Special notes

It should be used with caution in patients with epilepsy, convulsive syndrome of a different etiology, with severe impaired renal and hepatic function. During treatment, patients should receive a sufficient amount of fluid (under the control of diuresis).

Norfloxacin should be taken no less than 2 hours before or 2 hours after taking antacids or preparations containing iron, zinc, Magnesium, Calcium or sucralfate.

Drug interaction

With simultaneous use of norfloxacin with Warfarin increases the anticoagulant effect of the latter.

With the simultaneous use of norfloxacin with cyclosporine, an increase in the concentration of the latter in the blood plasma is observed.

While taking Norfloxacin and antacid agents or drugs containing iron, zinc, magnesium, calcium or sucralfate, absorption of norfloxacin is reduced due to the formation of complexones with metal ions (the interval between their intake should be at least 4 hours).

When taken simultaneously, Norfloxacin reduces theophylline clearance by 25%, therefore, with simultaneous use, reduce the dose of theophylline.

Simultaneous administration of norfloxacin with drugs that have the potential ability to reduce blood pressure, can cause a sharp decrease. In this regard, in such cases, as well as with the simultaneous introduction of barbiturates, anesthetics, heart rate, blood pressure, ECG indicators should be monitored. Simultaneous use with drugs that reduce the epileptic threshold may lead to the development of epileptiform seizures.

Reduces the effect of nitrofurans.