Pantogam pills 500mg №50

Pantogam&№174;

hopantenic acid

Dosage form

pills

Composition

1 pill contains: active ingredient: Calcium hopantenate (Pantogam&№174;) 500 mg; excipients: methylcellulose 1.6 mg, calcium stearate 6.2 mg, Magnesium hydroxycarbonate 93.6 mg, talc 18.6 mg.

nootropic agent

Pharmacology

The spectrum of action of Pantogam&№174; is associated with the presence of gamma-aminobutyric acid in its structure. The mechanism of action is due to the direct influence of Pantogam&№174; on the GABAH receptor-channel complex. The drug has a nootropic and anticonvulsant action. Pantogam&№174; increases brain resistance to hypoxia and the effects of toxic substances, stimulates anabolic processes in neurons, combines a moderate sedative effect with a mild stimulating effect, reduces motor excitability, and activates mental and physical performance. Improves GABA metabolism in chronic alcohol intoxication and after the abolition of ethanol. It is able to inhibit acetylation reactions involved in the inactivation mechanisms of procaine (novocaine) and sulfonamides, which results in a prolonged action of the latter. It causes inhibition of the pathologically increased gallbladder reflex and detrusor tone.

Pantogam&№174; is rapidly absorbed from the gastrointestinal tract, penetrates the blood-brain barrier, the highest concentrations are created in the liver, kidneys, in the 2 wall of the stomach and skin. The drug is not metabolized and is excreted unchanged within 48 hours: 67.5% of the dose taken - with urine, 28.5% - with feces.

Indications and usage

- cognitive impairment in organic brain lesions, including the effects of neuroinfections and traumatic brain injuries, and neurotic disorders;

- with extrapyramidal hyperkinesis in patients with hereditary diseases of the nervous system in combination with therapy;

- as a corrector for the side effects of antipsychotics, for neuroleptic extrapyramidal syndrome (hyperkinetic and akinetic), as part of complex therapy for cerebral organic failure in patients with schizophrenia; - epilepsy with a slowdown of mental processes in complex therapy with anticonvulsants;

- psycho-emotional overload, reduced mental and physical performance, to improve concentration and memorization;

- neurogenic disorders of urination (pollakiuria, urgency, imperative urinary incontinence, enuresis);

- children with delayed development (mental, speech, motor or a combination thereof), including against the background of perinatal encephalopathy and in children with various forms of cerebral palsy;

- children with hyperkinetic disorders (attention deficit hyperactivity syndrome);

- children with neurosis-like conditions (tics; stuttering, mainly in the clonic form).

Contraindications

- hypersensitivity;

- acute severe kidney disease;

- pregnancy;

- breastfeeding period;

- children&№39;s age up to 3 years.

In conditions of long-term treatment, simultaneous administration of the drug with other nootropic and stimulating agents is not recommended.

Pregnancy and Breastfeeding

The use of the drug during pregnancy and during breastfeeding is not recommended due to the lack of experience of clinical use in this category of patients.

Inside, in 15-30 minutes after eating. A single dose for adults is usually 0.25-1 g (&№189;-2 tablets), for children - 0.25-0.5 g (&№189;-1 tablet); The daily dose for adults is 1.5-3 g (3-6 tablets), for children - 0.75-3 g (1.5-6 tablets). The course of treatment is from 1 to 4 months, in some cases up to 6 months. After 3-6 months, it is possible to repeat the course of treatment. For cognitive impairment with organic brain lesions, including the effects of neuroinfections and head injuries, and neurotic disorders: 0.25 g (&№189; tablet) 3-4 times a day. In extrapyramidal hyperkinesis in patients with hereditary diseases of the nervous system in combination with therapy: at a dose of 0.5 to 3 g (1-6 tablets) per day. The course of treatment is up to 4 months or more.

As a corrector with the side effects of neuroleptic drugs, with neuroleptic extrapyramidal syndrome (hyperkinetic and akinetic), as part of complex therapy for cerebral organic failure in patients with schizophrenia: adults - in a dose of 0.5 to 1 g (1-2 tablets) 3 times per day; children - at a dose of 0.25 to 0.5 g (&№189;-1 tablet) 3-4 times a day. The course of treatment is 1-3 months. In epilepsy with a slowdown of mental processes in complex therapy with anticonvulsant drugs: adults - at a dose of 0.5 to 1 g (1-2 tablets) 3 times a day; children - at a dose of 0.25 to 0.5 g (&№189;-1 tablet) 3-4 times a day. The course of treatment is up to 6 months.

When psycho-emotional overload, reducing mental and physical performance, to improve concentration and memorization: 0.25 g (&№189; tablet) 3 times a day. In neurogenic disorders of urination: adults - at a dose of 0.5 to 1 g (1-2 tablets) 2-3 times a day; children - at a dose of 0.25 to 0.5 g (&№189;-1 tablet) 3 times a day (daily dose is 25-50 mg / kg). The course of treatment is 1-3 months. Children with various pathologies of the nervous system, depending on age, are advised to take up to 3 g per day (6 tablets). Tactics of administration of the drug: increasing the dose within 7-12 days, taking the maximum dose for 15-40 days and gradually reducing the dose until Pantogam&№174; is canceled within 7-8 days. The interval between Pantogam&№174; coursework, as for any other nootropic agent, is from 1 to 3 months. Children with developmental delay: 0.5 g (1 tablet) 3-4 times a day. The course of treatment is 2-3 months. For children with attention-deficit hyperactivity syndrome, depending on body weight, the drug is prescribed in an average therapeutic dose of 30 mg / kg per day, in the morning and in the afternoon, with dose titration during the first 5-7 days. The course of treatment is 3-4 months. Children with neurosis-like conditions (ticks; stuttering, mainly in the clonic form): at a dose of 0.25 to 0.5 g (&№189;-1 tablet) 3-6 times a day. The course of treatment is 1-4 months.

Taking into account the nootropic action of the drug, its administration is carried out preferably in the morning and afternoon hours (up to 17 hours). The drug is used in children older than 3 years. At an earlier age, it is recommended to take the drug in the form of a syrup.

Overdosage

Symptoms: sleep disturbance or drowsiness, noise in the head. Treatment: Activated carbon, gastric lavage, symptomatic therapy.

Storage conditions

At a temperature not higher than 25 ° С. Keep out of the reach of children.