Pantocalcin pills 500mg №50
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Mechanism of action
PANTOCALCIN has nootropic and anticonvulsant effects. The mechanism of action is associated with the presence in the chemical structure of GABA; interacts directly with the GABA-receptor-channel complex. Stimulates anabolic processes in neurons, increases the utilization of glucose and oxygen by the brain. It has neurometabolic, neuroprotective and neurotrophic effects, increases brain resistance to hypoxia and the effects of toxic compounds. Normalizes the function of neurons and restores lost functions, has an anticonvulsant effect, reduces psychomotor agitation. Activates mental and physical disability. Able to inhibit acetylation reactions of procaine and sulfonamides (inhibits inactivation and prolongs the action).
Rapidly absorbed in the digestive tract, the maximum concentration in the blood is reached within 1 h after administration. It penetrates the BBB, maximum concentrations are reached in the tissues of the liver, kidneys, the wall of the stomach and skin. Not metabolized and excreted from the body for 48 hours unchanged: 67.5% of the dose is excreted by the kidneys, the rest is excreted in the feces.
Indications and usage
Cognitive impairment in organic brain lesions (including the effects of neuroinfections and traumatic brain injuries) and neurotic disorders; extrapyramidal hyperkinesis (myoclonus epilepsy, Huntington's chorea, hepatolenticular degeneration, Parkinson's disease, etc.) as a means of correcting extrapyramidal syndrome (hyperkinetic and akinetic) caused by the administration of neuroleptics; epilepsy (in combination with anticonvulsants); psycho-emotional overload, reduced mental and physical performance, to improve concentration and memorization; urination disorders of different etiology (polakiuria, imperative urges, imperative urinary incontinence, enuresis); mental retardation in children.
Hypersensitivity to the drug, acute kidney disease, gestation period (I term).
Dosage and administration
Inside 15–20 minutes after eating. Admission dose for adults - 0.5–1 g, for children - 0.25–0.5 g; The daily dose for adults is 1.5–3 g, for children, 0.75–3 g. The course of treatment is from 1 to 4 months, in some cases up to 6 months. After 3-6 months, it is possible to repeat the course of treatment.
Children with mental retardation of 0.5 g 4-6 times a day for 3 months; when speech development is delayed by 0.5 g 3-4 times a day for 2–3 months.
As a means of correction in neuroleptic syndrome, adults are prescribed 0.5–1 g 3 times a day, children — 0.25–0.5 g 3–4 times a day.
In epilepsy, children are prescribed 0.25–0.5 g 3–6 times a day, adults 0.5–1 g 3–4 times a day for a long time (up to 6 months).
With ticks, children are prescribed 0.25–0.5 g 3–6 times a day for 1–4 months, adults –– 1.5–3 g / day for 1–5 months.
For urination disorders, adults are prescribed 0.5–1 g 2–3 times a day, children — 0.25–0.5 g (daily dose 25–50 mg / kg). The course of treatment is from 2 weeks to 3 months.
The maximum daily dose for children is: at the age of 2 months to 1 year - 0.5–1 g; from 1 to 3 years - 1.5–2 g; from 3 to 15 years - 2.5–3 g.
Allergic reactions (rhinitis, conjunctivitis, skin rash), sleep disturbance or drowsiness, tinnitus. These symptoms are usually short-lived and do not require discontinuation of the drug.
With prolonged treatment is not recommended simultaneous administration of the drug with other nootropic and CNS stimulating agents. Prolongs the action of barbiturates, enhances the effect of anticonvulsants, prevents the side effects of phenobarbital, Carbamazepine, antipsychotics. The effect of the drug is enhanced when combined with Glycine, ksidifonom. Potentiates the action of local anesthetics (procaine).
Characterized by increased severity of side effects. Treatment: gastric lavage, the appointment of Activated carbon, symptomatic therapy.
In the reach of children, dry, the dark place at temperatures up to 25 ° CPantocalcin