Perfalgan solution for infusions 10mg/ml 100ml №12

Overdosage

The clinical picture of acute overdose develops in the first 24 hours after taking Paracetamol in a high dose. Symptoms of chronic overdose appear 2-4 days after increasing the dose of the drug.

Symptoms:
- Acute overdose: diarrhea, loss of appetite, nausea, vomiting, discomfort and / or abdominal pain, pallor of the skin. With simultaneous administration of paracetamol to adults at a dose of 7.5 g or more, and children more than 140 mg / kg, cytolysis of hepatocytes occurs with complete and irreversible liver necrosis, development of liver failure, metabolic acidosis and encephalopathy, which can lead to coma and death. After 12.8 h after the introduction of paracetamol, an increase in the activity of hepatic transaminases, LDH and bilirubin levels and a decrease in the level of prothrombin are observed.
- Chronic overdose: develops a hepatotoxic effect, characterized by common symptoms (pain, weakness, weakness, increased sweating) and specific, characterizing damage to the liver. As a result, hepatonecrosis may develop. Hepatotoxic effect of paracetamol may be complicated by the development of hepatic encephalopathy (thought disorders, CNS depression, agitation and catatonia), the occurrence of seizures, respiratory depression, coma, brain swelling, bleeding disorders, the development of DIC, hypoglycemia, metabolic acidosis, arrhythmia, collapse. Rarely, liver dysfunction develops with lightning speed and may be complicated by renal failure (tubular necrosis).

The drug should be stored at a temperature of 15 ° to 30 ° C.