Postinor pill 0.75 mg №2

white, flat, disc-shaped with cut edges, marked "INOR" on one side.
1 pill contains levonorgestrel 0.75 mg;
Excipients: anhydrous colloidal silicone, Magnesium stearate, talc, corn starch, potato starch, lactose monohydrate;
in a blister strip package 2 pcs., in a box 1 pack.

Mechanism of action

Postcoital hormonal contraceptive for oral administration. Synthetic progestogen with pronounced progestogenic and antiestrogenic properties. It causes inhibition of ovulation, changes in the endometrium, prevents implantation of a fertilized egg. Increases viscosity of cervical mucus, which prevents the promotion of sperm.
The effectiveness of contraception decreases with increasing time elapsed between sexual intercourse and taking the drug: the effectiveness of contraception is 95% if Postinor is taken in the first 24 hours, 85% - between 24 and 48 hours, and 58% - between 48 and 72 hours.
When the recommended doses are observed, levonorgestrel does not significantly affect blood coagulation factors, fat and carbohydrate metabolism.

Suction
After ingestion, levonorgestrel is rapidly and completely absorbed from the gastrointestinal tract. C_max active substance in plasma is marked after 1.6 h and amounts to 14.1 ng / ml.
Distribution
Levonorgestrel is associated with albumin and globulin that binds sex hormones. It is excreted in breast milk; with breastfeeding about 0.1% of levonorgestrel with the breast milk enters the body of the child.
Metabolism
Levonorgestrel is metabolized in the liver, its biotransformation corresponds to the metabolism of steroids. Pharmacologically active metabolites of levonorgestrel are unknown.
Removal
The concentration of levonorgestrel in plasma decreases in two phases. T_1/2 is 2-7 hours. 60% is excreted by the kidneys, 40% through the intestines.

Indications and usage

Emergency post-coital contraception in women with a regular menstrual cycle after unprotected sex, as well as in cases where the method of contraception used cannot be considered reliable.The postinor is recommended for use as an alternative hormonal contraceptive in the following emergency situations: during unprotected intercourse, if the contraceptive method used cannot be considered reliable (rupture, slippage or misuse of the male condom, shift, rupture or premature removal of the diaphragm or cervical plate, failure the use of interrupted sexual intercourse Whether the removal of intrauterine contraceptive, skipping three or more pills when receiving hormonal oral contraceptive for continuous use), rape.

Dosage and administration

Postinor is prescribed at a dose of 750 mcg (1 tab.) Within 48 hours (but no later than 72 hours) after intercourse, and 12 hours after taking the first dose, another 750 mcg (1 tab.) Of the drug is taken.
For 1 course can receive no more than 2 tab.
If vomiting occurs within 2 hours after taking the drug, then taking the pills should be repeated.
The drug can be used on any day of the menstrual cycle, provided that the last menstruation was normal.
Tablets are taken orally, regardless of the meal, without chewing, with a small amount of liquid.

Adverse reactions

On the part of the endocrine system: menstrual irregularities (including bloody intermenstrual bleeding), a feeling of tension in the mammary glands, delayed menstruation.
Gastrointestinal: nausea, vomiting, diarrhea.
Other: fatigue, dizziness.

Contraindications

- Severe diseases of the liver or biliary tract;
- genital bleeding of unknown etiology (including metrorrhagia);
- Thrombosis of arteries and veins;
- thromboembolism (in history);
- delayed menstruation;
- pregnancy (including estimated);
- hypersensitivity to the drug.
Relative contraindication
- puberty.

Pregnancy and breastfeeding

Postinor is contraindicated for use during pregnancy.
During lactation (breastfeeding), Postinor is used for strict indications; the possible effect of levonorgestrel on a child can be minimized if the patient takes both pills immediately after feeding and then misses the feeding.

Special notes

It is not allowed to use Postinor as a means of permanent and continuous contraception, sinceThis leads to a decrease in the effectiveness of the drug and an increase in adverse reactions.
Re-use of the drug Postinor should be avoided during the same menstrual cycle due to possible irregularities in the menstrual cycle.
If the delay in the onset of regular menstruation is more than 5 days, pregnancy should be excluded.
If bleeding occurs, a gynecological examination should be performed.
With regular sex life should use permanent methods of contraception.
Influence on ability to drive motor transport and control mechanisms
The drug does not adversely affect the ability to engage in potentially hazardous activities that require increased attention and speed of psychomotor reactions.

Overdosage

Symptoms: nausea, menstrual disorders.
Treatment: if necessary, symptomatic therapy is carried out, there is no specific antidote.

Drug Interactions

With the simultaneous use of Postinor with inducers of hepatic enzymes, the metabolism of levonogestrel increases.
When used together, rifampicin, ampicillin, tetracyclines, barbiturates (including primidone), phenytoin, Carbamazepine, ritonavir, rifabutin, Griseofulvin reduce Postinor's contraception effect.
With simultaneous use with Postinorom increases the toxicity of cyclosporine due to inhibition of its metabolism.

Storage conditions

The drug should be stored out of reach of children at a temperature of 15-25 ° C.