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Zulbex pills 10 mg №28
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Dosage form
Enteric-Coated Tablets
Composition
1 tab. contains Rabeprazole sodium 10 mg
Packing
28 pcs.
Mechanism of action
Zulbex is an antiulcer agent from the group of proton pump inhibitors (H + / K + -ATP-ase), it is metabolized in the parietal cells of the stomach to active sulfonamide derivatives, which inactivate the sulfhydryl group H + / K + -ATP-ase.
Blocks the final stage of secretion of HCl, reducing the content of basal and stimulated secretion, regardless of the nature of the stimulus. It has a high lipophilicity, easily penetrates into the parietal cells of the stomach and concentrates in them, providing a cytoprotective effect and increasing the secretion of bicarbonate.
The antisecretory effect after oral administration of 20 mg occurs within 1 hour and reaches a maximum after 2-4 hours; Inhibition of basal and food-stimulated acid secretion after 23 hours after the first dose is 62 and 82%, respectively, the duration is 48 hours. After the end of the reception, the secretory activity is normalized within 2-3 days.
In the first 2-8 weeks of therapy, the concentration of gastrin in the serum increases and returns to baseline within 1-2 weeks after withdrawal. It does not affect the central nervous system, cardiovascular and respiratory systems.
Indications and usage
Peptic ulcer and 12 duodenal ulcer (treatment), gastroesophageal reflux disease, Zollinger-Ellison syndrome, stressful ulcers of the gastrointestinal tract.
As part of complex therapy: Helicobacter pylori eradication in patients with gastric ulcer and duodenal ulcer or chronic gastritis; treatment and prevention of recurrence of peptic ulcer associated with Helicobacter pylori.
Contraindications
Hypersensitivity, pregnancy, lactation.
Carefully. Children's age, severe renal failure.
Dosage and administration
Inside, on 20 mg once a day, in the morning. The course of treatment for gastric ulcer and duodenal ulcer - 4-6 weeks, if necessary - up to 12 weeks; with reflux esophagitis - 4-8 weeks.
The pills are swallowed whole, not chewed or crushed.
Adverse reactions
Nausea, constipation or diarrhea, abdominal pain, flatulence, headache, dizziness, drowsiness, weakness, skin rash, increased activity of liver transaminases, thrombocytopenia, leukopenia; pharyngitis, rhinitis, asthenia, back pain, flu-like syndrome, myalgia, dry mouth, calf muscle cramps, arthralgia, fever.
Rarely - loss of appetite, weight gain, depression, blurred vision or taste sensation, stomatitis, increased sweating.
Before and after treatment, endoscopic control is necessary to exclude a malignant neoplasm, since treatment can mask the symptoms and delay the correct diagnosis.
The drug does not affect the function of the thyroid gland, carbohydrate metabolism, the concentration of parathyroid hormone, cortisol, estrogen, testosterone, prolactin, cholecystokinin, secretin, glucagon, FSH, LH, renin, aldosterone and somatotropic hormone.
Drug Interactions
Slows the excretion of certain drugs that are metabolized in the liver by microsomal oxidation (diazepam, phenytoin, indirect anticoagulants).
Reduces the concentration of Ketoconazole by 33%, Digoxin - by 22%.
Storage conditions
At a temperature not higher than 30 ° C.