Timolol eye drops 0.5% 5ml

Eye drops 0.5%:
1 ml contains timolol maleate 6.8 mg, which corresponds to the content of timolol 5 mg;
Excipients: disodium phosphate dodecahydrate, sodium dihydrogen phosphate monohydrate, disodium edetate dihydrate, sodium chloride, benzalkonium chloride, sodium hydroxide, purified water;
in a vial of 5 ml with a stopper dropper.

Mechanism of action

Antiglaucoma drug is a non-selective beta-blocker. When applied topically, Timolol reduces intraocular pressure by reducing the formation of aqueous humor and a small increase in its outflow. The effect manifests itself in 20 minutes after instillation, the maximum effect in 1-2 hours. The duration of action is 24 hours.

Indications and usage

 
- open-angle glaucoma;
- secondary glaucoma (including uveal, aphakic, post-traumatic);
- acute increase in intraocular pressure;
- angle-closure glaucoma (in combination with miotics).

Contraindications

- bronchial asthma;
- sinus bradycardia;
- AV blockade II and III degree;
- acute and chronic heart failure;
- cardiogenic shock;
- dystrophic diseases of the cornea;
- rhinitis;
- Hypersensitivity to the components of timolol.
The drug should be used with caution in severe COPD, sinoatrial blockade, arterial hypotension, cerebrovascular insufficiency, chronic heart failure, diabetes mellitus, hypoglycemia, thyrotoxicosis, myasthenia, simultaneous administration of other beta-adrenoblockers, as well as in pediatric patients (especially during infancy), because the drug contains benzalkonium chloride).

Pregnancy and Breastfeeding

Use of Timolol during pregnancy is possible only when the intended benefit to the mother exceeds the potential risk to the fetus.
If necessary, the use of the drug during lactation should decide on the termination of breastfeeding.

Dosage and administration

Adults and children over 10 years old are buried in the conjunctival sac, 1 cap of a 0.25% solution 2 times a day, with insufficient effectiveness, 1 cap of a 0.5% solution 2 times a day. With the normalization of intraocular pressure maintenance dose - 1 cap 0.25% 1 time per day. The difference in the severity of action of 2 concentrations is 10-15%. Newborns and children up to 10 years old - 1 drop of a 0.25% solution 2 times a day.

Adverse reactions

Local reactions: irritation of the conjunctiva - conjunctival hyperemia, tearing or reduction of tearing, photophobia, swelling of the corneal epithelium, burning and itching in the eyes, eyelid hyperemia, short-term visual impairment; blepharitis, conjunctivitis, keratitis, with prolonged use may develop surface point keratopathy (decrease in the transparency of the cornea) and decrease the sensitivity of the cornea, possible ptosis, rarely - diplopia. Systemic reactions: paresthesia, rhinitis, nasal congestion, nasal bleeding, decrease in blood pressure, collapse, bradycardia, bradyarrhythmia, AV blockade, reduction of myocardial contractility, exacerbation of CHF manifestations; headache, dizziness, drowsiness, hallucinations, depression, myasthenia gravis, decreased potency; shortness of breath, bronchospasm, pulmonary insufficiency; nausea, vomiting, diarrhea, chest pain, tinnitus. Slowing down the speed of psychomotor reaction. Allergic reactions (including urticaria).

Special notes

Care must be taken when driving a car at night, and to avoid activities that place high demands on adaptation to poor lighting. Monitoring the effectiveness is recommended approximately 3-4 weeks after the start of therapy (no earlier than 1-2 weeks). With prolonged use of Timolol, the effect may be weakened.

Store in a cool and dark place, protected from light and moisture, at a temperature not higher than 25 ° C.