Vancomycin freeze-dried powder for injection 0.5 g №1

1 bottle contains vancomycin (in the form of hydrochloride) 0.5 g.

Packing

Bottle 0.5 g.

Mechanism of action

An antibiotic of the group of glycopeptides. Vancomycin-Teva has a bactericidal effect. Disrupts cell wall synthesis, permeability of the cytoplasmic membrane and synthesis of bacterial RNA. Active against gram-positive bacteria: Staphylococcus spp. (including strains producing penicillinase and methicillin-resistant strains), Streptococcus spp., Enterococcus spp., Corynebacterium spp., Listeria spp., Actinomyces spp., Clostridium spp. (including Clostridium difficile). No cross-resistance with other antibiotic groups was observed.

Indications and usage

Neuritis of the auditory nerve, I trimester of pregnancy, marked impaired renal function, hypersensitivity to vancomycin.

Pregnancy and Breastfeeding

The use of Vancomycin-Teva in the first trimester of pregnancy is contraindicated due to the risk of nephro- and ototoxicity. The use of vancomycin in the II and III trimesters is possible only for health reasons. If necessary, use during lactation breastfeeding should be discontinued.

Use in the II-III trimester of pregnancy is possible only for "vital" indications. When prescribing to premature and normal newborns, control over serum concentration is desirable. When taken concomitantly with general anesthetics, the frequency of side effects increases, so vancomycin is best administered before general anesthesia. During the period of treatment, an audiogram, determination of kidney function (urinalysis, creatinine and urea nitrogen) are necessary. It is desirable to determine the concentration of vancomycin in the serum (in renal failure, in patients older than 60 years).Maximum concentrations should not exceed 40 mcg / ml, and the minimum - 10 mcg / ml. Concentrations in excess of 80 mcg / ml are considered toxic.

Composition

1 bottle contains vancomycin (in the form of hydrochloride) 0.5 g.

Dosage and administration

Vancomycin-Teva administered in / in the drip. Adults - 500 mg every 6 hours or 1 g every 12 hours. To avoid collaptoid reactions, the duration of the infusion should be at least 60 minutes. Children - 40 mg / kg / day. Each dose should be administered for at least 60 minutes. In patients with impaired renal excretory function, the dose is reduced taking into account the CC values. Depending on the etiology of the disease, vancomycin can be taken orally. For adults, the daily dose is 0.5-2 g in 3-4 doses, for children - 40 mg / kg in 3-4 doses. The maximum daily dose for adults with a / in the introduction of 3-4 g.

Drug Interactions

When administered simultaneously with local anesthetics in children, erythematous rashes and flushing of the skin of the face may appear, in adults - a violation of intracardiac conduction. Not recommended co-administration with nephrotoxic and ototoxic drugs (aminoglycoside, amphotericin B, ASA or others. Salicylates, bacitracin, bumetanide, capreomycin, carmustine, paromomycin, cyclosporine, "loop" diuretics, polymyxin B, Cisplatin, ethacrynic acid). Kolestiramin reduces efficacy. Antihistamine drugs, meklozin, phenothiazines, thioxanthenes can mask the symptoms of the ototoxic effect of vancomycin (tinnitus, vertigo). General anesthetics and vecuronium bromide - the risk of lowering blood pressure or developing neuromuscular blockade. Vancomycin infusion is possible at least 60 minutes before their introduction.

Overdosage

Symptoms: increased severity of side effects.
Treatment: symptomatic in combination with hemoperfusion and hemofiltration.

Storage conditions

At a temperature of 15–30 ° C