Zinnat suspension 125mg/5ml vial 50ml

Packaging

Bottle for the preparation of 50 ml of suspension.

Mechanism of action

Zinnat is a II generation cephalosporin antibiotic for oral administration. Bactericidal effect, violates the synthesis of the cell wall of bacteria. It has a wide spectrum of action.

Resistant to most beta-lactamase.

Zinnatathighly active againstaerobic gram-positive bacteria:Staphylococcus aureus, Staphylococcus epidermidis (including strains that are resistant to penicillins and with the exception of rare methicillin-resistant strains), Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus group B (Streptococcus agalactiae, etc., in line with a hint of a hint, in line with a hint of a hint, in a group of people who are resistant to the disease).aerobic gram-negative bacteria: Escherichia coli, Klebsiella spp., Proteus mirabilis, Providencia spp., Proteins, all of which have a look at the tomb of the Holy See and not producing penicillinase), Neisseria meningitidis, Salmonella spp.;anaerobic gram-positive bacteria: Peptococcus spp., Peptostreptococcus spp., Clostridium spp., Propionibacterium spp.;anaerobic gram-negative bacteria: Bacteroides spp, Fusobacterium spp.; alsoactive against Borrelia burgdorferi.

To cefuroximeare resistant Clostridium difficile, Pseudomonas spp., Campylobacter spp., Acinetobacter calcoaceticus, Listeria monocytogenes, methicillin-resistant strains of Staphylococcus aureus, methicillin-resistant strains of Staphylococcus epidermidis, Legionella spp.

In vitro studies have shown that the combination of cefuroxime with antibiotics from the group of aminoglycosides has an additive effect, and in some cases synergism.

Indications and usage

Treatment of infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

• respiratory tract infections (including acute and chronic bronchitis, infected bronchiectasis, bacterial pneumonia, lung abscess, postoperative infections of the chest organs);
• infections of the ear, nose and throat (including sinusitis, tonsillitis, pharyngitis, acute otitis media);
• infections of the genitourinary system (including acute and chronic pyelonephritis, cystitis, urethritis, asymptomatic bacteriuria);
• infections of the skin and soft tissues (including furunculosis, pyoderma, impetigo);
• gonorrhea (including acute uncomplicated gonococcal urethritis and cervicitis);
• treatment of Lyme disease at an early stage and the subsequent prevention of late manifestations in adults and children over 12 years of age.

Contraindications

Hypersensitivity to the antibiotics of the cephalosporins group.

Carefully used in the first trimester of pregnancy and lactation.

Dosage and administration

Children under the age of 12 You can prescribe the drug in the form of a suspension.
The average dose for most infections is 125 mg (1 scoop of suspension or 1 tab.) 2 times a day.
With severe infections or otitis media in children aged 2 years and older the average dose is 250 mg 2 times a day.

In case of mild to moderate infectious diseases a single dose set at the rate of 10 mg / kg body weight.

The duration of the drug is 5-10 days.

The drug is recommended to be taken after meals.

Adverse reactions

Gastrointestinal: nausea, vomiting, diarrhea; perhaps a temporary increase in the activity of liver enzymes (ALT, AST, LDH), jaundice; Cases of pseudomembranous colitis are described.
Hemic and lymphatic: hemolytic anemia, eosinophilia, neutropenia, thrombocytopenia, leukopenia (sometimes pronounced).
Allergic reactions: skin rash, pruritus, urticaria, fever, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, serum sickness; in isolated cases - anaphylaxis.
From the side of the central nervous system: headache.
Other: Coombs' positive reaction.

Special notes

With prolonged use of Zinnat, enhanced growth of resistant microorganisms (Candida, Enterococci, Clostridium difficile) is possible, which may require cessation of treatment.

When diarrhea appears on the background of the use of antibiotics, incl. Zinnat, it should be borne in mind the possibility of pseudomembranous colitis.

When treated with Zinnat Lyme disease, the Jarish-Gersheimer reaction is sometimes noted. This reaction is a direct consequence of the bactericidal action of Zinnat on the causative agent of the disease - the spirochete Borrelia burgdorferi. Patients need to be explained that this is a frequent and common, spontaneous passing of a consequence of Lyme disease antibiotics treatment.

Drug Interactions

Simultaneous administration of cefuroxime and probenecid leads to an increase in AUC of cefuroxime by 50%.

Store at a temperature not higher than 25 ° С.